UNIT 5 Autonomic Nervous System Agents Flashcards
Nervous System
- Central Nervous System
- Peripheral Nervous System
- Central Nervous System
- Peripheral Nervous System
A. Somatic Nervous System
B. Autonomic Nervous System
A. Somatic Nervous System
B. Autonomic Nervous System
- Sympathetic
- Parasympathetic
stimulate sympathetic response
Agonist
block sympathetic response
Antagonist
– fight or flight
SYMPATHETIC NERVOUS SYSTEM
SYMPATHETIC NERVOUS SYSTEM
Effects
- heart rate, bp = increased, GI decreased, mydriasis - dilation
of the pupils
SYMPATHETIC NERVOUS SYSTEM
epinephrine, adrenaline
Neurotransmitters
SYMPATHETIC NERVOUS SYSTEM
alpha and beta receptors
Receptors
SYMPATHETIC NERVOUS SYSTEM
– target – blood vessels
Alpha receptors
SYMPATHETIC NERVOUS SYSTEM
– stimulant
Alpha 1
SYMPATHETIC NERVOUS SYSTEM
– control
Alpha 2
SYMPATHETIC NERVOUS SYSTEM
– target – 1 heart, 2 lungs
Beta receptors
SYMPATHETIC NERVOUS SYSTEM
vasoconstriction - increase heart rate, contraction, mydriasis,
increases blood pressure
Alpha 1 receptor agonist
Examples: phenylephrine, epinephrine
SYMPATHETIC NERVOUS SYSTEM
vasodilation – decrease in bp
Alpha 2 receptor agonist
- Example – Clonidine
SYMPATHETIC NERVOUS SYSTEM
increased heart contractility and heart rate – (Presence of dysrhythmia – hold the ordered dose and inform the doctor) - Increased myocardial contractility
Beta 1 receptor agonist
SYMPATHETIC NERVOUS SYSTEM
– bronchodilation
Beta 2 receptor agonist
Example : Albuterol – the nurse should monitor the patient for palpitations
SYMPATHETIC NERVOUS SYSTEM
blocks both A1 and A2
Non- Selective Alpha Antagonist
Example: Phentolamine
SYMPATHETIC NERVOUS SYSTEM
– blocks only Alpha 1 causing vasodilation,
decrease heart rate, contractility and bp.
Alpha 1 Selective Antagonist
Example: Phentolamine
SYMPATHETIC NERVOUS SYSTEM
blocks only Alpha 1 causing vasodilation, decrease heart rate, contractility and bp
Alpha 1 Selective Antagonist
Example: Prazosin
SYMPATHETIC NERVOUS SYSTEM
Beta Blockers
- Non Selective
- Selective B1 antagonist/blocker
SYMPATHETIC NERVOUS SYSTEM
blocks both B1 and B2 causing vasodilation decreasing bp but
bronchoconstriction – don’t give to patient with asthma or respiratory problems.
Non Selective
Example : Propranolol
SYMPATHETIC NERVOUS SYSTEM
blocks only B1 causing
vasodilation causing a decrease in BP but no bronchoconstriction
Selective B1 antagonist/blocker
Example : Metoprolol – less likely to precipitate bronchoconstriction
rest and digest
PARASYMPATHETIC NERVOUS SYSTEM
PARASYMPATHETIC NERVOUS SYSTEM
Effects=
heart rate, bp = decreased, GI increased, miosis
Cholinesterase inhibitors
Parasympathomimetics
Acetylcholine
Neurotransmitters
mimic Acetylcholine
cholinergic agonists
Receptors
Nicotinic and Muscarinic
target skeletal muscles
Nicotinic receptors
target – smooth muscles, salivary glands, gastrointestinal stimulation
Muscarinic receptors
increase salivation, sweating, urination, gastric acid
Muscarinic agonist
Example: Pilocarpine
skeletal muscle contraction
Nicotinic receptor agonist
will cause miosis, diarrhea and bradycardia
Bethanechol
Nursing management
Perform urinary assessment
clinical manifestation of extreme muscarinic stimulation
Excessive perspiration
as a neuromuscular relaxan
Succinylcholine
cholinesterase inhibitor
Physostigmine
bradycardia, hypotension, bronchospasm
Side effects
antimuscarinic agents causing bladder relaxation preventing urinary incontinence.
Vasico selective
Example: Oxybutynin – treatment for bladder incontinence – will cause decrease unrination
muscarinic antagonists – decrease saliva, mucus secretions, prevent vomiting
Antidote for excessive dosing of bethanechol
Atropine
increase temp, confusion, flushed face, dryness of mouth, very thirsty
Atropine overdose
muscle relaxation
Neuromuscular blocking drugs
nicotinic receptor antagonist
Spasmolytics
Example - Dantrolene – skeletal muscle relaxation
dilation of pupils
Mydriatics
antimuscarinic agents causing bladder relaxation preventing urinary incontinence.
Vasico selective
Example: Oxybutynin – treatment for bladder incontinence – will cause decrease unrination
muscarinic antagonists – decrease saliva, mucus secretions, prevent vomiting
Antidote for excessive dosing of bethanechol
Atropine
increase temp, confusion, flushed face, dryness of mouth, very thirsty
Atropine overdose