Unit 5 Flashcards
What is Inflamation
cellular, tissue or vascular reaction to irritation, infection, or injury
What is Phlegmon
inflammation of connective tissues
Inflamations Functions:
-protective defense mechanism -isolates & destroys the invader -cleans up the debris to promote healing -DOES NOT include REPAIR
Inflammation: Etiology
-physical irritants – trauma, burns, radiation -chemical irritants – e.g., irritating gases -infectious agents – viruses, bacteria -immunological reactions (autoimmune disease) – e.g., rheumatoid arthritis, lupus erythematosus
What is the Inflammatory Process
Tissue injury triggers the following events: - tissue mast cells (white blood cells) release histamine –> vasodilation (increased diameter of blood vessel capillaries) –> hyperemia (increased blood flow to the area) –>formation of inflammatory exudate (thick liquid around infection site due to blood fluid leaking from blood vessel to tissue) –> edema - neutrophils and macrophages (white blood cells) move toward the site (chemotaxis) to destroy debris and bacteria (phagocytosis)
What is Hyperemia
An increase in blood supply. This brings more WBC to the area - neutrophils (WBC) escape from blood vessel into the injured tissue by diapedesis (squeeze through the capillary wall) - phagocytosis (destroys microorganisms & foreign material) - suppuration (production & discharge of pus) ***pus = dead cell + exudate
Inflammation: Cardinal Signs and Symptoms
Based on the steps of the inflammatory process, it explains the cause of: heat (calor)redness (rubor)swelling (tumor)pain (dolor)altered function (functio laesa)
Inflammatory Lesion - Abscess
Abscess – localized, circumscribed accumulation of pus
Inflammatory Lesion - Ulcer
Ulcer - open sore or lesion of skin (epidermis) or mucous membrane accompanied by sloughing of inflamed necrotic tissue
Inflammatory Lesion - Vesicle
Vesicle - blister-like elevation of skin containing serous fluid
Inflammatory Lesion - Furuncle
Furuncle (boil) - abscess or pyogenic (producing pus) infection of sweat gland or hair follicle
Inflammatory Lesion - Carbuncle
Carbuncle - several communicating boils of skin & subcutaneous tissues with production & discharge of pus & dead tissue
Inflammatory Lesion - Pustule
Pustule - small elevation of skin containing pus
What is Exudate
- fluid mixture of proteins, leukocytes, and tissue debris - oozes through tissues into cavity or to surface
Inflammatory Exudate - Serous
- Serous – clear serum-like fluid containing primarily fluid, with small amount of proteins, implies lesser injury (damage); e.g., skin blisters, cold sores
Inflammatory Exudate - Purulent
- Purulent – largely inflammatory cells (neutrophils), tissue debris & pyogenic bacteria (pus)
Inflammatory Exudate - Hemorrhagic
Hemorrhagic – increased number of red blood cells (due to damaged leaking blood vessels), often infected, very serious condition
Inflammatory Exudate - Fibrinous
Fibrinous - rich in fibrinogen; coagulates and forms fibrin; produces a sticky film on surface of inflamed tissue; indicates larger injury; e.g., strep throat, bacterial pneumonia