Unit 4 stuff; cancer Flashcards

1
Q

what are the stages of cancer metastasis

A
  1. cancer is confined to organ of origin
  2. cancer is locally invasive
  3. cancer spreads to regional structures (ex,, lymph nodes)
  4. cancer has spread to distant areas of body
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2
Q

what type of cancer does a pap smear screen for?

A

cervical cancer

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3
Q

what type of cancer does a mammogram screen for?

A

breast cancer screening

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4
Q

What is one way you can check for prostate and ovarian cancer

A

blood tests

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5
Q

how can you screen for colon cancer

A

fecal occult blood test (test to find smallest amount of blood in the stool), and colonoscopy.

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6
Q

how is cancer diagnosed

A

biopsy;microscopic examination

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7
Q

what do scientists look for when looking for cancer

A

irregular shaped cells, awk size and shape of a nucleus and the cell size and shape, loss of specialized cellular features, no more organized tissue, poor tumor boundary.

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8
Q

what is anaplasia

A

loss of mature characteristics (less mature characteristics)

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9
Q

what is autonomy

A

loss of response to environmental signals.

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10
Q

what is the most common type of cancer

A

carcinomas

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11
Q

what part of body do carcinomas form?

A

cells covering external and internal body surfaces; ex) lung, breast, colon

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12
Q

what part of body do sarcomas form/affect

A

supporting tissues of body; ex) bone, cartilage, fat, connective tissue, muscle.

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13
Q

what part of the body do lymphomas form and affect

A

lymph nodes; ex) immune system body tissue

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14
Q

what part of the body do leukemia form and affect

A

immature blood cells that grow in bone marrow; will often build up in large numbers in blood stream

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15
Q

what does the prefix adeno mean

A

gland

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16
Q

what does the prefix chrondro mean

A

cartilidge

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17
Q

what does the prefix erythro mean

A

red blood cell

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18
Q

what does the prefix hemangio mean

A

blood vessels

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19
Q

what does the prefix hepato mean

A

liver

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20
Q

what does the prefix lipo mean

A

fat

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21
Q

what does the prefix lympho mean

A

lymphocyte

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22
Q

what does the prefix melano mean

A

pigment cell

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23
Q

what does the prefix myelo mean

A

bone marrow

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24
Q

what does the prefix myo mean

A

muscle

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25
Q

what does the prefix osteo mean

A

bone

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26
Q

what are factors associated w benign tumors

A

slow growing, well differentiated (cell composition), looks like original tissue, well-defined capsule, no metastasis

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27
Q

what factors are associated with malignant tumors

A

rapid growth, frequent mitosis, poorly differentiated, not encapsulated, invades local tissues, spreads easily(blood + lymphatics)

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28
Q

what are a few things that inc risk for cancer

A

tobacco use, sunshine, x-ray, viruses, bacteria, stomach cancer, hereditary.

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29
Q

what is the single largest cause of death from cancer

A

smoking

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30
Q

What can HIV patients develop that looks like skin lesions, but is a malignant tumor of blood vessels located in the skin.

A

KSHV

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31
Q

what is H. pylori

A

a bacteria that causes stomach ulcers… can possibly lead to cancer

32
Q

is cancer generally an inherited disease

A

no.

33
Q

hereditary retinoblastoma can lead to what cancer?

A

retinoblastoma

34
Q

xeroderma pigmentosum can lead to what cancer?

A

skin cancer

35
Q

wilms’ tumor can lead to what cancer?

A

kidney cancer

36
Q

li-fraumeni syndrome can lead to what cancer?

A

sarcomas, brain, breast and lukemia

37
Q

familial adenomatous polyposis can lead to what cancer?

A

colon and rectum cancer

38
Q

pagets disease of bone can lead to what cancer?

A

bone cancer

39
Q

faconi’s aplastic anemia can lead to what cancer?

A

lukemia, liver, and skin cancer.

40
Q

How many genes are in 1 cell

A

30,000 genes

41
Q

what do genes make for the cells

A

protein

42
Q

how do all cancers begin

A

when 1 or more genes mutate it creates abnormal proteins; this allows cell to rapidly multiply and become cancerous

43
Q

what is the most common cause of cancer though genetic mutations

A

acquired mutations is the most common cause of cancer

44
Q

is acquired mutations passed parent to child

A

no

45
Q

how do aquired mutations occur

A

they happen when a person damages the genes throughout their life

46
Q

what is a germline mutation

A

when a mutation is passed parent to child

47
Q

are germline mutations or aquired mutations more common

A

aquired mutations are more common

48
Q

what does oncongenes do

A

turn helathy cells into cancer cells; NOT INHERITED

49
Q

what genes are linked to cancer (name em)

A

BRCA1, BRCA2, P53

50
Q

what do DNA repair genes do

A

fix mistakes made when DNA is copied; many are tumor suppressor genes.

51
Q

what are the factors that affect the invasion/local spread of the cancer

A
  • how fast cells are replicating and dying
  • mechanical pressure (local tissue death makes tumor cells spread rapidly.
    -increasing release of lytic enzymes
  • tumor cells can easily slip between normal cells making them spread quickly
  • have increased motility.
52
Q

what is the dependent factor for cancer to metastasis by implantation

A

adequate blood supply to new tumor colonies (angiogenesis)

53
Q

what is it called when a tumor shows a preference for a certain organ

A

organ tropism

54
Q

what is the most common “scheme” of staging a tumor

A

TNM
T- tumor spread
N - lymph node involvement
M- presence of distant metastasis.

55
Q

what does “T” mean

A

tumor

56
Q

what does “N” mean

A

Node

57
Q

what does “M” mean

A

metastasis

58
Q

what symptoms come along with early onset cancer

A

usually no pain; later on pain, fear, anxiety, sleep loss etc can occur

59
Q

what is pain management treatment in cancer

A

1) control pain
2)prevent reoccurance
3) constant re-evaluation of pain

60
Q

what is another word for fatigue

A

malaise

61
Q

what is the most reported symptom of cancer

A

fatigue

62
Q

what is another word for cachexia

A

wasting

63
Q

is anemia a symptom of cancer

A

yes; lack of blood

64
Q

what can cause chronoic hemorrhage in cancer patients

A

thrombocytopenia

65
Q

what does leukopenia result in sometimes

A

a serious infection

66
Q

what is surgery treatment used for

A

nonmetastatic cancer

67
Q

what is chemotherapy treatment used for

A

single or combo of agents; attack cancer cells @ diff stages of its life cycle

68
Q

what is radiation treatment used for

A

eradicate cancer without producing too much toxicity in body

69
Q

what is immunotherapy treatment used for

A

tumor- specific vaccine to target only cancer cells; monoclonal antibodies

70
Q

what is mohs surgery

A

a precise surgical technique to treat skin cancer (thin layers of the cancerous tissue is removed until only non-cancerous tissue is left)

71
Q

what are some side-effects of cancer treatments

A
  • GI tract; oral ulcers, malabsorption, diarrhea, inc risk of infections (nausea sometimes)
    -cannabis and opiods sometimes helps
    -have really good oral hygene
    -hair and skin loss
    -dec fertility and early menopause
72
Q

How common is cancer in children

A

RARE; HOWEVER it is the second leading cause of death in children who live past 1 year

73
Q

does childhood cancer involve tissue or organs

A

tissue ; organs = adults

74
Q

most common cancers in children?

A

sarcomas, leukemia, lymphomas

75
Q

what is the cause of cancers

A

unknown –> (immunosupressions, chromosomal abnormalities, prenatal exposure to some drugs, childhood exposure to secondhand smoke, ionizing radiation.