Unit 4 Dosage Forms

Question 1

dysphasia

Answer 1

nausea and vomiting
oral administration is not suitable and one has to opt for other routes such as parenteral,
topical or inhalation

Question 2

Binders function

Answer 2

Promotes cohesiveness of powders
Provides mechanical strength to tablet

Question 3

Binders examples

Answer 3

Carboxymethylcellulose
Methylcellulose
Povidone

Question 4

Diluents function

Answer 4

Inert substance
Used as filler to provide required bulk of tablet
Provides better tablet properties

Question 5

Diluents examples

Answer 5

Water soluble- lactose, sucrose, sorbitol
Water insoluble- microcrystalline cellulose, starch, calcium phosphate

Question 6

Lubricant function

Answer 6

An additive to reduce friction during tabletting
Also helps tablet to overcome various defects like lamination, sticking and chipping

Question 7

Lubricant examples

Answer 7

Magnesium stearate
Stearic acid
Calcium stearate

Question 8

Glidant function

Answer 8

Improve powder flow properties of formulation

Question 9

Glidant examples

Answer 9

Talc
Aerosil
Calcium silicate

Question 10

Disintegrant function

Answer 10

used in solid dosage forms to break up a dosage form after oral administration
contributes to increase in SA - faster dissolution

Question 11

absorbent function

Answer 11

used in formulation to absorb semisolid or liquid excipientsa

Question 12

antioxidant function

Answer 12

added to tablet formulation to delay/inhibit oxidation process

Question 13

What should enteric coating/gastroresistant tablets not be taken with and why?

Answer 13

Not be taken with indigestion remedies (antacids)
which either directly neutralize acidity, increasing the pH, or reversibly reduce or block
the secretion of acid by gastric cells to reduce acidity in the stomach.

Question 14

oral suspensions should

Answer 14

contain flavouring and sweetening to mask unpleasant tastes

Question 15

topical suspensions should

Answer 15

be free from any type of gritty particles to prevent irritation on skin

Question 16

parenteral suspensions (iv and im) should be

Answer 16

sterile and free from foreign particles

Question 17

opthalmic suspensions should be

Answer 17

sterile and free from foreign particles

Question 18

when are suspensions used

Answer 18

people who have difficulty swallowing
absorption rate of drug is quicker in suspension
drugs with low solubility

Question 19

extemporaneous preparation

Answer 19

necessary to treat patients who needs cant be fulfilled by commercially produced products
may be asked to make a liquid form of a drug that is usually a tablet.

Question 20

major parenteral routes

Answer 20

intravascular
intramuscular
subcutaneous
transdermal
inhalation