UNIT 3- REPRODUCTION CONTRACEPTION & INFERTILITY Flashcards
In pubery the hypothalamus secretes what hormones?
- Gonadotropin-releasing hormone (GnRH)
In puberty the anterior pituitary secretes what hormones?
- Follicle-stimulating hormone (FSH)
- Leteinizing hormone (LH)
During puberty what is happening with the ovaries and testes doing?
Increasing production of sex hormones (gametes)
Male and female reporductive systems are similar in utero for how long?
until the 1st 6 weeks
What secretes the primary sex hormones?
Ovaries and testes
During childhood the sex glands are…. active or inactive
inactive
When do reporductive organs become functional?
Puberty
What should we know about puberty changes in males?
(when does it happen, what triggers it, and what secondary sex characteristics will we see?)
- Puberty- capable of reproduction- 13.5 y/o age
- Triggered by the production of testosterone
- secondary sex characteristics
- Skeletal growth
- increases in body composition
- devleop body hair- facial, axillary and pubic
- Voice changes
- Enlargment of testes and penis
- noctural emissions (wet dreams) not usually mature sperm tho
What should we know about female puberty changes?
(when does it happen, what triggers it, and what secondary sex characteristics will we see?)
- Puberty- capable of reproduction- 8-13 y/o age
- Triggered by the production of estrogen
- Secondary sex characteristics
- Develope body hair-axillary, legs & pubic area
- Body contours-widening of hips
- Skeletal growth
- Reproductive organs
- Breast changes- mamary ducts & nipples erect
- 1st menstrual period-2-2.5 years after puberty
What are the structures of a female reproductive system?
- Ovaries
- Fallopian tubes
- Uterus
- Cervix-internal and external os
- Vagina
The anterior pituitary hormone FSH’s function is?
Helps control menstrual cycle & production of eggs by ovaries
The anterior pituitarys hormone LH’s function is
A surge causes ovulation and results in formation of corpus luteum
The ovaries release estrogen and its funciton is?
- THickens uterine lining and regulates growth, development & physiology of reproductive system
The ovaries release progesterone and its function is?
- Prepares the lining of the uterus to impant and grow a fertilized egg; inhibits FSH & LH
What are the 4 phases of the menstrual cycle?
- Menstrual phase
- Proliferative phase
- Ovulatory phase
- Luteal phase
In the menstrual cycle what is the menstrual phase?
- Day 1 to Day 5
- changes we might see- mood swings, tender breast, cravings, irritable
In the menstrual cycle what is the proliferative phase?
- Day 5-14 end of menstral- pituitary secretes FSH which makes the egg, LH which houses the egg and starts produceing progesterone
In the menstrual cycle what is the ovulatory phase?
- This is where your best shot of pregnancy occurs- marked increase in the LH and FSH hormone, getting ready for egg.
- Only 1 egg per month
Think 0 for egg
In the menstrual cycle what is the luteal phase?
- During this phase, levels of FSH and LH decrease in response to higher levels of estrogen and progesterone. If the ovum is fertilized it secreats a hormone that causes persistence of corpus luteum to maintain an early pregnancy
- If the ovum is not fertilized, FSH and LH fall to low levels and the corpus luteum regress.
- Decline of estrogen and progesterone along with corpus lutum regression results in menstrauation as the uterine lining breaks down.
The menstrual cycle is caused by
hormone changes
What are the 4 phases in the endometrial cycle?
- menstrual phase
- Proliferative phase
- Secretory phase
- Ischemic phase
The endometrial cycle is driven by…
What is happening to the lining physcially
In the endometerial cycle what is the menstrual phase?
Vasocontriction and shedding of the lining which sloths off
In the endometrial cycle what is the proliferative phase?
- Occurs as the ovum matures and is released during the first half of the ovarian cycle. After completion of a menstrual period, the endometrium is very thin. The basal layer of the endometrial cells remain after menstration. These cells multply to form new endometrial epithelium and endometral glands under the stimulation of estrogen secreated by the maturing ovarian follicles. Endometrial sprial arteries and endometerial veins elongate to accompany thickening of the functional endometrial layer and nourish proliferating cells. As oculation approches, the** endometrial glands secrete thin, stringy mucus that aids entry of sperm into the uterus.**
In the endometrial cycle what is the secretory phase?
- The secretory phase occurs during the last half of the menstrual cycle as the uterus is prepared to recieved a fertilized ovum. The endomentrium contines to thicken under the influence of estrogen and progesteron from the corpus luteium. Reaching its maxium thickness.
- If pregnancy does not occur lining will be shed off again
In the endometrial cycle what is the ischemic phase?
Vasospasm of the endometrial blood vessels causes the endometrium to become ischemic and necrotic. THe necrotic areas of the endometrium separate from basal layers, which results in the menstrual flow.
What conditions must be met for fertilization to happen?
1.Fallopian tubes are patent
2.Semen is supportive to pregnancy
3.Adequate progesterone & thickening endometrium of uterus(endometrial biopsy)
4.Live,motile, normal sperm are present (postcoital test)
What are signs of ovulation?
- Drop in basal body temp: Occurs 1 day before ovulation and remains elevated 10-12 days
- Spinbarkeit Mucus: abundant, watery thin, clear, stretchy (egg white)
- Cervical os dilates slightly, softens and rises in the vagina
- Mittelschmerz occurs: localized abdoinal pain
- Saliva ferning: seen under microscope
- Increased libido
What is spinnbarkeit mucus?
Abundant, watery thin, clear stretch (eggwhite) mucus
What does the cervical os do during ovulation?
Dilates slightly, softens and rises in the vagina
What is Mittelschemez?
Localized abdominal pain during ovulation
usually on one side and occurs about 14 days before the next period
While educating a patient on the reporductive cycle, the nurse should plan to inculde that ovulation occurs when the….
blood level of LH is too hihgh
What is infertility?
Inability to conceive/maintain a pregnancy after 12 mos. of unproteted intercourse
if older than 35 then only 6 months
What is primary infertility?
Never conceived
What is secondary infertility?
Couples who have concieved before but are unable to conceive again
Why types of stress can infertility cause?
- Mentally-inability to concieve
- Financially-expenses
- Emotionally- effect on couples relationship can be see as a crisis in the relationship
What are some causes of infertility in men?
- Abnormal erections
- Abnormal ejection
- Abnormalities of seminal fluid
- Abnormalities of sperm
- abnormal hormonal stimulation
- Acute or chornic illness (mumps, cirrhosis of the liver, renal function)
- Anatomic abnormalities such as varicocele (enlargment of veins behind teste, absence of a teste)
- Exposure of toxins such as lead, pesticides or other chemicals
- Antineoplastic drugs– chemo or radiation
- Excessive alcohol intake; use of illicit drugs-effects sperm motility
- elevated scrotal temps
- Immunologic factors produced by man or women
How can abnormal ejection in men cause infertility?
- Retrograde ejaculation- semen enters the bladder instead of the penis
- Diabetes
- Neuologic disoder
- Antihypertensives and psychotropics
How can abnormalities of seminal fluid in men cause infertility?
- Obstructions/infection of the gential tract
How can abnormalities of the sperm cause infertility?
- Azoospermia
- Oligospermia
What is Azoospermia?
Absent sperm in semen
What is oligospermia?
Decreased sperm in semen
How does infections of the gential tract cause infertility?
r/t inflammation which can cause sperm to clump so it isnt able to move as fast or penatrate and that cause it not be able to fertilized
How can elevated scrotal temps can cause infertility what things might we teach male patients so they know what might cause the elevated temps?
- febrile illness
- use of saunas or hotubs or sitting for long periods
What types of disorders in ovulation can cause infertility in women?
- Hypothalamus or pituitary gland dysfunction-not able to secrete needed hormones
- Failure of ovaries to respond to follicle stimulating hormone(FSH)
- PCOS: most common
- cranial tumors
- stress
- obesity or anorexia
- systemtic disease
- abnormalities in ovaries or other endocrine glands- polyps cause scaring which creates a hostile cervical mucus so instead of thinning it might thicken
What abnormalities of the fallopian tubes can cause infertility in women?
- Endometriosis- tissue lining has grown outside of the uterus where it does not belong
What abnormalities in the cervix can cause infertility in women?
- Estrogen levels decreased preventing the developement of spinnbarkeit- if this is decreased we have thick cervical mucus which causes sperm to not be able to travel
Recurrent pregnancy loss is considered part of infertility in women what factors in this can cause infertility?
- Abnormalities of fetal chromosomes
- Abnormalties of the cervix or uterus
- endocrine abnormalities
- immunologic and thrombotic factors- increase risk of miscarrage
- environmental agents
- Infections- effect uterine lining which effects implantation and egg cannot implant
During our evaluation of infertility what information should we collect during the history and physical exam
ask
- Reproductive medical history
- menstrual history- how periods have been normal or irregular
- any pregnancies, complications and outcomes
- Contraceptives methods-past and present
- Fertility with other partners (pervious success)
- Pattern of intercourse
- Exposure to toxins
- Medications-RX or OTC
- Family history of pregnancy loss
- Home tests/other methods use (test for ovulation)
What diagnostic tests for men can we run to look at fertility?
Men are usually tested first-cheaper and quicker
1. Semen analysis- collection after 2-3 days of abstinence
2. Ultrasonography- checking for obsturction & abnormalities
3. Hormone analysis
- FSH, LH, Testosterone & prolactin
4. Testicular biopsy- usually done for little or no sperm
5. Sperm penetration assay- “hamster test” human sperm mixed with pretreated hamster eggs to see if it can penetrate it
What diagnostic test can we run to look at fertility in women?
- Ovulation prediction-basal body temp.. spinbarket assesment to look at the details of cervical mucus
- Xray of uterus & fallopian tubes to determine patency
- Hormone analysis- progesterone, FSH, estrogen, LH & prolactin
What are nonmedical therapies and alternative measures used to help faciliate pregnancy?
- Nutritional and dietary changes- losing weight– 5-10% loss can usually resotre ovulation
- Exercise, yoga and stress managment
- Lifestyle changes-no smoking/drinking
- Ovulation predictor- knowing whats going on in the body
- Use water soluable lubricant for intercourse- avoid chemical because it can misleaad ovulation reading cause it causes cervical mucus to thin maturely so you think your ovulating when you are not
What is a pharmocologic therapy we can use to help facilitate pregnancy?
Clomiphene citrate and letrozole
1. ACTION: stimulates pituitary gland to increase secretion of luteinizing hormone (LH) & FSH, can cause ovarian hyperstimulation syndrome
- Ovarian stimulation
- Oral medication
- Risk of multiple gestations
2. Metformin: adjunctive treatment for infertility due to PCOS
What are the side effects of of clomiphene citrate and letrozole?
- hot flashes
- blurred vision
- n/v
- Pain in pelvis
- bloating
- Headache
Clomiphene citrate and letrozole is contraindicated with
- Bleeding diorders or liver disease
What is In Vitro fertilization- embryo transfer (IVF-ET)?
Reporductive technology- Eggs are collected from ovaries, fertilized in the lab with sperm; embryo then transferred to the uterus
Fertilization outside of the body
What is intrauterine insemination (IUI)
Reproductive technology- places prepared sperm in the uterus at time of ovulation
Fertilization inside the body
What is intracytoplasmic sperm injection?
Assisted reporduction- single sperm selected and injected directly into mature oocyte in the lab
fertilization outside the body
What is gamete intrafallopian transfer (GIFT)
Assisted reproduction- oocytes retrieved placed with prepared motile sperm; then placed in fallopian tubes
Fertilization inside body
What are our nursing implications and interventions for fertility help/procedures?
- Educate on available options for reporductive assistance and encourage couples to discuss feeling about infertility
- Educate couple on roles of specialists they will see
- Monitor for adverse effects associated with associated with infertility treatments
- Teach that infertility medications that can increase risk of multiple births
- Refer for psychosocial counsling if needed
- Educate regarding assisted reorductive therapies and available options such as surrogacy and adoptions
What should we know about the development of the placenta?
- Formed from both fetal and maternal tissue
- Exchange of substances between mother and fetus occurs in intervillous spaces of placenta
- Placental membrane seperates to prevent maternal and fetal blood mixing; gasses, nutrients and electrolytes are exhanged via umbilical cord
- Viruses (such as rubella & cytomegalovirus and drugs CAN cross placental membrane and enter fetal circulation
What is a degenerative placenta?
Infarcts & calcifications that interfere with uterine-placental-fetal oxygen exchange
When is a degenerative placenta more likely?
- severe preeclampsia
- smokers
- drug abuse
- post date
The amniotic sac is formed by what two membranes?
Amnion and Chorion; they appear to be one membrane-usually rupture together
What contined within the amniotic sac?
Embryo and amniotic fluid
What is the purpose of amniotic fluid?
- Cushions impact to maternal abdomen
- Prevents adherence of fetus to amniotic membranes
- Allows freedom freedom of fetal movement
- Provides a consistent thermal enviroment
- Essential for fetal lung development
- Allows symmetric development as major body surfaces fold to midline
What is oligohydramnios?
Abnormally small quanity of fluid (<50% of amount expected for gestion or <400ml at term)
What can oligohydraminos cause?
- poor placental blood flow
- Preterm premature rupture of membranes
- Failure of kidney development
- Blocked urinary tract
- Fetal effects
- Poor fetal lung development
- Malformation such as skeletal abnormalities
Oligohydraminos causes an increase risk of….
Cord compression because the fluid is what helps prevent and cushion
what is polyhydraminos?
- Quantity of fluid may exceed 2000 mL
What can polyhydraminios cause?
- Poorly controlled maternal diabetes mellitus resulting in large quantities of fetal urine excretion having elevated glucose level
- Malformations of CNS, cardiovasular system of GI tract
- Chromosomal abnormailities
- Multifetal gestation
Sometimes has no known cause
Polyhydraminos can cause increased risk of…
PPH due to streatching of uterus