Unit 3 - 3: Psychopathy and Schizophrenia

Question 1

Psychiatric diseases have a —- cause

Answer 1

Physiological cause

Question 2

In many psychiatric diseases

Answer 2

There are genetic, epigenetic, and environmental influences in the presence, severity, and recovery of disease

Question 3

Schizophrenia (5)

Answer 3

1. Hallucinations (mostly auditory, like voices
2. Intense fear from unseen enemies
3. Disordered thinking
4. Excited motor behavior
5. Affect in emotion; blunting/ withdrawal

Question 4

Importance of twin studies in complex disorders

Answer 4

Reveal genetic and environmental causes (monozygotic = same genes 50% concordance, dizygotic = 17% concordance)

Question 5

Genetic, Epigenetic, and environmental roots in schizophrenia (5)

Answer 5

1. Over 100 genes associated
2. DISC 1 is important (synaptic plasticity)
3. Paternal age
4. stress
5. physical environment (people who live in large cities more susceptible; pollution, crowds, sensory stimulation, stress, greater exposure to disease)

Question 6

Anatomical differences in schizophrenic brain (4)

Answer 6

1. Accelerated cortical thinning
2. Reduced activity in corpus calllosum
3. Enlarged ventricles
4. Under active frontal cortex

Question 7

Schizophrenia treatments (2)

Answer 7

1. Lobotomy (old practice) - severing frontal lobe from rest of brain
2. Chlorpromazine (Thorazine) - block D2 dopamine receptors

Question 8

Schizophrenia neurotransmitters (3)

Answer 8

1. Dopamine (not the whole story)
2. Serotonin (lots of second generation drugs target this
3. Glutamate (PCP antagonizes NMDA receptor; never an option cause activating = seizures

Question 9

Side effects of anti psychotics (2)

Answer 9

1. Long term use (especially of first gen D2 antagonists) lead to movement disorder (Tardive dyskinesia )
2. Cessation of drugs cause worse symptoms than before the drugs - super sensitivity psychosis

Question 10

Paralytic Dementia

Answer 10

Personality changes, mood swings, delusions