Unit 2: Pituitary & Adrenal Issues

Question 1

2 hormones found in the Posterior Pituitary

Answer 1

Oxytocin
ADH (Vasopressin)

Question 2

7 hormones found in the Anterior Pituitary

Answer 2

Acth**
GH**
TSH**
LH
FSH
Prolactin (PL)
Mylenocyte Stimulating Hormone (MSH)

Question 3

Adrenal glands secretes (3)

Answer 3

1. Cortisol (stress hormone)
2. Aldosterone (mineralocorticoid)
3. Catecholamines (E + NE)

Question 4

S/S of Hypopituitarism

Answer 4

Loss of secondary sex characteristics (loss of libido, facial/axillary/pubic hair, amenorrhea, infertility, breast atrophy)
Vision changes, HA, reduced cognition (tumor)
Short stature (children)
Osteoporosis, muscle loss, wt gain (adults)
Cold intolerance, anorexia, fatigue

Question 5

Hypopituitarism effect on Na+ and Glucose

Answer 5

Hypoglycemia
Hyponatremia

Question 6

S/S of Hyperpituitarism (Hyperfunction)

Answer 6

HA, vision changes (tumor = increased ICP)
wt gain
Bone and joint pain, changes in hands/facial features
Decreased libido, lactation, sterility

Question 7

Test for GH deficiency r/t Hypopituitarism

Answer 7

Provocative Testing

Question 8

Test for GH r/t Hyperpituitarism

Answer 8

Suppression Testing
- give glucose

Question 9

Suppression Testing results in decreased GH

Answer 9

EXPECTED RESPONSE; NOT GH Hyperpituitarism

Question 10

Suppression Testing results in increased GH

Answer 10

GH Hyperpituitarism

Question 11

Drug classes for Tx of Hyperpituitarism

Answer 11

Dopamine Agonist
Somatostatin Analogs (octreotide)
GH-receptor blockers (pegvisomant)

Question 12

What are the main ADRs r/t Dopamine agonists for Tx of hyperpituitarism?

Answer 12

Orthostatic hypotension
GI irritation (give with food)
Rare: Dysrhythmias + CSF leakage