Unit 1: Medications Flashcards
Amiodarone MOA
Class III Antidysrhythmic
- Blocks K+-channels (prolongs diastole)
- Decreases HR, contractility, + conductivity
(negative inotrope, chronotrope, dromotrope)
Antiadrenergic
Blocks beta-1 receptors (vasodilation)
Amiodarone is used to treat (2)
- Afib
- Atrial flutter
- pulseless Vfib
- SVTs (off-label use)
Diltiazem MOA
CCB (effect on heart same as BBs)
- blocks Ca2+ influx in sm. muscle, preventing contraction
- Decreases HR, contractility, + conductivity
- Vasodilation → Increases cardiac perfusion
Diltiazem is used to treat ()
- Afib
Dronedarone MOA
Antidysrhythmic, Antiadrenergic
block K+, Na+, Ca2+-channels
Dronedarone is used to treat ()
- Afib
Atropine MOA
Anticholinergic
- Blocks PNS to increase HR
Atropine is used to treat ()
- Sinus bradycardia
Ivabradine MOA
Hyperpolarization-activated cyclic nucleotide-gated
(HCN) channel blocker
- Selectively and specifically inhibits SA node conductivity, lowering HR
Meds for Sinus Tachycardia
- BBs
- CCBs
- Digoxin
(Not mentioned: Ivabradine)
Meds for Sinus Tachycardia
- BBs
- CCBs
- Digoxin
(Not mentioned: Ivabradine)
Meds for Sinus Bradycardia
- Atropine
Meds for Afib
- Diltiazem** (DOC)
- Amiodarone (2nd-line DOC)
- Dronedarone
- BBs (Atenolol, Metoprolol)
- Digoxin (HF-related)
- Anticoagulants
Meds for non-perfusing PVCs
BBs
Meds for VTach
- Amiodarone