Unit 2 Flashcards
in what 5 steps did the vertebrate in the cns develop ?
1.vertebrae folds within itsself
2. Neural plate border comes together from each side as one
3. The epidermis fuses and seals it into a oval and lays on top
4. The plate border break off and become neural crest cells
5. The neural plate left becomes a neural tube
what happens at 4 week in the development of the CNS and what are the 4 parts
the back end of the neural spinal splits into the three regions ( forebrain, hinebrain, midbrain , spinal cord)
what happens at week 6 in the development of the CNS
what 3 parts does it split into and what are within those parts
the tube splits into major brain regions present at birth
Hindbrain:
Medulla
Cerebellum and pons
Midbrain as one
Forebrain:
diencephalon
cerebrum
what happens at week 11 in the development of the CNS
the smooth cerebrum grows rapidly
what happens at birth in the development of the CNS
cerebrum take up majority of brain
what protects the brain
the cranium
what protects the spine
the veterbrae
what are the 3 layers of connective tissue surrounding the brain and spine ?
Dura mater is outermost
Arachnoid in the middle
Pia mater is innermost
what is the fluid between the layer ?
cerbral spinal fluid
the cns is surrounded by meninges
aka dura, arachnoid pia
how much fluid filled with CSF ventricles does the brain have and what are they
4 , 2 lats ,3rd vents 4 vent
how much fluid filled with CSF is in the spine
1
what is the choroid plexus
it is patches of and ependymal cell that produce CSF
Do all the ventricles in the brain produce CSF
yes
what does the ependymal cells do ?
they form a barrier between blood vessels & CSF
when there is high amounts of protein or a presence cell in the CSF what does that suggest ?
a possible infection
how many time is CSF removed and replaced in a day
4
what are the other extracellular fluid of the CNS?
interstital fluid and plasma
what is interstital fluid ?
surrounds neurons and glilal cells
what is plasma ?
in cerebral blood vessels
Plasma has alot of high compements in comparasion to CSF like K+ CA+ etc what are the same of different between them
the same Na + sodium and
CSf has no blood cells
what are olgiodendrocytes ?
they form mylein in the CNS aka white matter
what are astrocytes ?
they regulate ecf
what is the circulation of CSF
start in lateral ventricles go to 3rd and fouth accumlate CSF and exit in the 4th vent to the sub arachoid it cicrulate and then goes the to the arachnoid villi within the dural sinus like a bulge and enters the dural sinus specifically the superior saggital sinus where it then goes to the spine
what is the superior saggital sinus
it is the the biggest component of the dural sinus and where CSF. goes to waste
what is hyrdocephalic ?
where csf and unable to exit and it cloggs up your brain and increases pressure and compresses your brain tissue
what is the astrocyte foot process ?
secret paracrine factors which promote tight juntions
what are tight junctions ?
it prevents solutes from moving in between cells
what is the blood brain barrier ?
a barrier that allow lipid soluble molecules to cross easily
hydrophillic substance with a transporter to cross
antihistamine dont cross
drugs that treat diseases are allowed to cross