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Neuroscience Exam 1 > Unit 1.Lec 5-Neuromuscular Junction and Postsynaptic Signaling > Flashcards

Unit 1.Lec 5-Neuromuscular Junction and Postsynaptic Signaling Flashcards

1
Q

Define Synaptic Transmission

A

(Postsynaptic signaling) Interpreting the transmitted signal and translation of the signal into a change in postsynaptic Vm

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2
Q

What does the Neuromuscular Junction (NMJ) trigger?

A

Skeletal muscle contraction and respiratory muscle control (involuntary+voluntary)

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3
Q

List the Classes of Membrane Receptors

A
  1. Ionotropic (Ligand-gated) -Fast response
  2. Metabotropic (GPCR) -Slow & Variable response

  1. Receptor kinases
  2. Receptor-linked kinases
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4
Q

What are Ionotropic (Ligand Gated) Receptors

A

Direct activation of the neurotransmitter receptor channel elicts fast respnse (PSPs)

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5
Q

Examples (5) of Ionotropic Receptors

A
  1. Nicotinic Acetylcholine Receptors (nACHR)-Acetylcholine (receptor @ NMJ) (Curare-antagonist; arrow poisoning paralyzing agent)
  2. NMDA & AMPA (Kainate) Receptors-Glumate (Ketamine-NMDA receptor antagonist; dissociative anesthetic)
  3. Serotonin Receptor Channel-5HT3 (Excitatory) (all 5-HT3 antagonist are antiemtic)
  4. GABA- Types A & C (Benzodiazepines, Kava, Valerian)
  5. Glycine Receptor (GlyR) (Glycine and Taurine-agonist; Strychnine-antagonist, rat poison)
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6
Q

What are Metabotropic (G-Protein Coupled) Receptors

A

Activation of G-Protein coupled receptors elicits slow PSP

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7
Q

Examples of Metabotropic Receptors

A
  1. Muscarinic Acetylcholine Receptor (mAChR)
  2. Metabotropic Glutamate Receptor (mGluR)
  3. Biogenic Amine Receptors (Serotonin-excluding 5HT3R, Dopamine, NE, Histamine)
  4. GABA Receptor (Type B)

Metabotropic Receptor structure 7 transmembrane segment

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8
Q

What are the three biochemica levents that can occur following metabotropic receptor activation?

A
  1. Directly activates/deactivates ion channels
  2. Activation of effector molecule synthesis (cAMP)
  3. Activation of 2nd messenger (IPS, Ca2+)
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9
Q

How does Metabotropic Receptor activation alters postsynaptic membrane potential?

A

By increasing/decreasing ion channel activity

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10
Q

What happens during signal mediated event?

A
  • The signal mediated through cAMP, IP3, Ca2+ to have an ion flux
  • Potential downstream cascades activated: PI3K/Akt, NFkB, PLC, and Ca/CaM
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10
Q

What happens during signal mediated event?

A
  • The signal mediated through cAMP, IP3, Ca2+ to have an ion flux
  • Potential downstream cascades activated: PI3K/Akt, NFkB, PLC, and Ca/CaM
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11
Q

Explain the casde of Metabotropic receptor

A
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11
Q

Explain the casde of Metabotropic receptor

A
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Neuroscience Exam 1 (9 decks)

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