Ulcerative Colitis Flashcards
What is Ulcerative Colitis
GI disease affecting the whole tract from the rectum to the colon
What are symptoms of Ulcerative Colitis
- bloody diarrhoea
- defecation urgency
- abdominal pain
What age is Ulcerative Colitis common in
15 to 25 years
What are complication of Ulcerative Colitis
- colorectal cancer
- osteoporosis
- VTE
What medication should you not use in treatment of diarrhoea in Ulcerative Colitis and why
- codeine
- loperamide
can cause toxic megacolon
What are the 5 levels of Ulcerative Colitis
1st: Proctitis
2nd: Proctosigmoiditis
3rd: DIstal
4th: Extensive Colitis
5th Pancolitis
How to treat Acute Proctitis (stage 1)
1st Line:
Topical aminosalisylate
if no improvement after 4 weeks
2nd Line:
add an oral aminosalisylate
3rd Line:
Topical or oral corticosteroid for 4 to 8 weeks
How to treat Acute Proctosigmoiditis/Distal (stage 2/3)
1st Line:
Topical aminosalisylate
2nd Line:
Topical aminosalisylate/corticosteroid + High dose aminosalisylate
3rd Line:
oral aminosalisylate + oral corticosteroid for 4 to 8 weeks
How to treat Acute Extensive Ulcerative Colitis (stage 4)
1st Line:
Topical aminosalisylate + High dose oral aminosalisylate
2nd Line:
high dose oral aminosalisylate + oral corticosteroid for 4 to 8 weeks
How to treat Acute Pancolitis (stage 5) (severe)
Hospital
1st Line:
IV Hydrocortisone/methylprednisolone
2nd Line:
+ IV Ciclosporin / Influcimab
3rd Line:
Surgery
What is the maintenance treatment for:
1st: Proctitis
2nd: Proctosigmoiditis
rectal ± oral aminosalicylate
What is the maintenance treatment for:
3rd: DIstal
4th: Extensive Colitis
oral low dose aminosalicylate
What is the maintenance treatment for 2+ flare ups in 12 months
1st Line:
oral azathiopurine / mercaptopurine
2nd Line:
monoclonal antibodies
Examples of Aminosalicylates
- Sulfasalazine
- Mesalazine
What colour dose Sulfasalazine stain body fluids / contacts
Yellow / orange
