Crohn's Disease Flashcards
What is Crohn’s Disease
deep ulceration though gastrointestinal tract
What are the complications of Crohn’s Disease
- Intestinal Fistula/stricture
- anaemia
- Cancer
- delayed growth in children
- Arthritis
- eye, liver and skin abnormalities
How to treat Acute Crohn’s disease with 1 flare up in 12 months
1st Line:
Prednisolone, methylprednisolone, IV Hydrocortisone
2nd Line:
Aminosalicylates
(Sulfasalzine and Mesalazine)
How to treat Acute Crohn’s disease with 2+ flare up in 12 months: 1st Line
1st Line:
Dual Therapy
Corticosteroid +
Azathioprine/Meraptopurine
How to treat Acute Crohn’s disease with 2+ flare up in 12 months: 2nd Line
2nd Line:
Dual Therapy
Corticosteroid + Methotrexate
How to treat Acute Crohn’s disease with 2+ flare up in 12 months: 3rd Line
Monoclonal Antibodies
What should you stop in order to help maintenance of Crohn’s Disease
Smoking
How to help Diarrhoea from Crohn’s Disease
- Codeine
- Loperamide
- Colestyramine
1st Line Maintenance treatment for Crohn’s Disease
Azathioprine / Metcaptopurine / Methotrexate
2nd Line Maintenance treatment for Crohn’s Disease
- Surgery
then after…
Azathioprine + Metronidazole
(if metronidazole not tolerated, do not use)
What is Fistulating Crohn’s Disease
fistula develops between intestine and perianal skin/bladder/vagina
What to do if Fistulating Crohn’s Disease is asymptomatic
Leave it alone
How to help improve Fistulating Crohn’s Disease
Metronidazole ± Ciprofloxacin
How long should you use Metronidazole for in Fistulating Crohn’s Disease
1 month
(max 3 months, due to peripheral neuropath)
What is the maintenance help for Fistulating Crohn’s Disease: 1st and 2nd Line
1st Line:
Azathioprine / Mercaptopurine
2nd Line:
Monoclonal Antibodies
(Infliximab)
