UC Flashcards
1
Q
pathology of UC
A
- hyperaemia/haemorrhagic granular colonic mucosa with or without pseudopolys formed by inflammation
- punctuate ulcers may extend deep into the lamina propria
- inflammation is not normally transmural
2
Q
complications of UC
A
- perforation and bleeding
- toxic dilation of the colon
- venous thrombosis
- colonic cancer
3
Q
symptoms of UC
A
- episodic or chronic diarrhoea (blood or mucus)
- crampy abdo discomfort
- frequency - increasing frequency is more severe
- urgency and tenesmus
- systemic symptoms in attacks (fever, malaise, anorexia, weight loss)
4
Q
signs in acute attack
A
fever, tachycardia, and a tender distended abdomen
5
Q
extra intestinal signs
A
clubbing aphthous ulcers erythema nodosum pyoderma gangrenous conjunctivitis episcleritis iritis large joint arthritis, sacroilitis, ankylosing spondylitis fatty liver PSC and cholangiocarcinoa nutritional deficits amyloidosis
6
Q
investigations in UC
A
- bloods
- stool MC&S/CDT to exclude campylobacter, C diff, salmonella, shigella, E coli and amoebae
- AXR - no faecal shadows, mucosal thickening/islands, colonic dilation
- colonoscopy
- biposy
7
Q
biopsy findings in UC
A
- inflammatory infiltrate
- goblet cell depletion
- glandular distortion
- mucosal ulcers
- crypt abscecces
