sjogrens syndrome

Question 1

pathophysiology of sicca symptoms

Answer 1

lymphocytic infiltration of exocrine glands

Question 2

sicca symptoms

Answer 2

mucosal dryness - eyes, mouth, larynx, pharynx, vagina

Question 3

types of sjogrens

Answer 3

• primary

- secondary (RA, SLE, systemic sclerosis, MTCD, autoimmune thyroid’s, primary biliary cirrhosis)

Question 4

symptoms of primary sjogrens

Answer 4

-fatigue
-dry eyes (gritty, dry, red, painful, risk of infection)
dry mouth (difficulty eating drug foods, dental caries, mouth ulcers)
-parotid and submandibularr gland swelling - infiltrative process, ductal stones - obstruction & localised lymphoma)
-vag dryness
increased risk of lymphoma

Question 5

antibody testing for sjogrens

Answer 5

RF
ANA
SSA (Ro)
SSB (La)
IgG+++
ESR +++>100

Question 6

other testing for sjogrens

Answer 6

schemer test
parotid and submandibular USS
minor labial gland biopsy
salivary flow

Question 7

symptomatic treatment

Answer 7

eye drops (eye surgical techniques)
saliva replacement
topical oestrogen creams

Question 8

immunomodulatory treatmetn

Answer 8

hydroxychloroquine