antiphospholid syndrome Flashcards
1
Q
diagnosis
A
at least once clinical feature + autoantibody (antiphospholipid antibody) on two separate occasions 12 weeks apart
2
Q
clinical events for diagnosis
A
vascular event - DVT, VTE, TIA, stroke
pregnancy - fetal death after 10 weeks gestation, premature birth due to preeclampsia or placental insufficiency, multiple embryonic losses
3
Q
autoantibodies
A
- anticardiolipin antibodies aCL
- antibodies to beta 2 glycoprotein beta-2-GP-I
- lupus anticoagulant
4
Q
clinical features
A
-livido reticularis
-cognitive defecvts
-haem: thrombocytopenis
-cardiac: valvular heart disease
-+ve Coombes test
renal impairment
5
Q
treatment
A
warfarin
