crony Flashcards
1
Q
what is crohns
A
chronic inflammatory disease characterised by transmural granulomatous inflammation affecting any part of the gut
skip lesions
2
Q
common parts affected
A
terminal ileum
proximal colon
3
Q
mutations at increased risk
A
NOD2/CARD15
4
Q
pathophysiology
A
dysfunctional reg T cells which normally control pro-inflammatory cytokine release
5
Q
symptoms
A
diarrhoea and urgency abdo pain weight loss failure to thrive fever malaise anorexia
6
Q
signs
A
aphthous ulcers
abdo tenderness/mass
perianal abscess/fistulae/skin tags
anal strictures
7
Q
extra intestinal manifestation
A
clubbing
erythema nodosum
large joints sero-negative arthritis
uveitis
8
Q
investigations
A
- blooda
- stool MC&S to exclude infective causes
- colonscopy and rectal biopsy (granulomas)
- small bowel enema, detects ileal disease
- capsule endoscopy
- colonscopy
- MRI
9
Q
complications
A
- small bowel obstruction
- toxic dilatation
- abscess formation
- fistulae
- perforation
- rectal haemorrhage
- colon cancer
- fatty liver and PSC and cholangiocarcinoma
- malnutrition
- amyloidosis
10
Q
treatment
A
- steroid (reduce inflammation)
- TNFalpha inhibitors
