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BMW > Tyrosine Receptor > Flashcards

Tyrosine Receptor Flashcards

1
Q

What are receptor tyrosine kinase?

A

Transmembrane proteins that contain kinase (protein)

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2
Q

What is the function of a kinase

A

It can phosphorylate a protein

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3
Q

What are the elements of an inactive receptor tyrosine kinase

A

Two monomers

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4
Q

What makes a receptor tyrosine kinase active

A

Signal molecule in the form of a dimer

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5
Q

Fill in the blank:
The right monomer will phosphorylate the … monomer and de left monomer will phosphorylate the … monomer

A

Left
Right

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6
Q

Is a phosphate positive or negative

A

Negative

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7
Q

What do the phosphates attract

A

Positive charges (adaptor proteins)

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8
Q

What will signal the cell

A

De positive charges that are connected to the phosphates

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9
Q

What does a adapter protein activate

A

Ras-activating protein

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10
Q

What does de Ras-activator protein do

A

Convert inactive ras protein in to active ras protein

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11
Q

What happens during the activation of the ras protein

A

GDP gets replaced by GTP

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12
Q

In what will the activation of ras protein result

A

Onward transmission of signal

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13
Q

What are the three proteins called that ras protein activates

A

MAP

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14
Q

I’m what order is MAP activated

A

MAP kinase kinase kinase
MAP kinase kinase
MAP kinase

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15
Q

How are the MAP kinases converted

A

Phosphorylation

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16
Q

What can de MAP proteins do

A

Phosphorylate a multitude of proteins

17
Q

What kind of proteins does MAP phosphorylate
Name 2

A

Those who change protein activity
Those who change gene expression

18
Q

In what result a mutation is Ras protein

A

GTP wil stay on the protein, so it’s signal won’t stop
Can result in tumors

19
Q

How do you mutate the receptor

A

By changing Y1 (or 2/3) to alanine

20
Q

What does alanine do in the mutated receptor

A

Will stop the phosphate from binding to that place

21
Q

What is de function of mutating a receptor

A

You can find out which protein bound to phosphate does what

22
Q

There are different kinds of mutations in de tyrosine receptor cascade but for what reason were they made

A

To figure out the order of the proteins, what activates what

BMW (4 decks)

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