Tyrosine Receptor Flashcards
What are receptor tyrosine kinase?
Transmembrane proteins that contain kinase (protein)
What is the function of a kinase
It can phosphorylate a protein
What are the elements of an inactive receptor tyrosine kinase
Two monomers
What makes a receptor tyrosine kinase active
Signal molecule in the form of a dimer
Fill in the blank:
The right monomer will phosphorylate the … monomer and de left monomer will phosphorylate the … monomer
Left
Right
Is a phosphate positive or negative
Negative
What do the phosphates attract
Positive charges (adaptor proteins)
What will signal the cell
De positive charges that are connected to the phosphates
What does a adapter protein activate
Ras-activating protein
What does de Ras-activator protein do
Convert inactive ras protein in to active ras protein
What happens during the activation of the ras protein
GDP gets replaced by GTP
In what will the activation of ras protein result
Onward transmission of signal
What are the three proteins called that ras protein activates
MAP
I’m what order is MAP activated
MAP kinase kinase kinase
MAP kinase kinase
MAP kinase
How are the MAP kinases converted
Phosphorylation
What can de MAP proteins do
Phosphorylate a multitude of proteins
What kind of proteins does MAP phosphorylate
Name 2
Those who change protein activity
Those who change gene expression
In what result a mutation is Ras protein
GTP wil stay on the protein, so it’s signal won’t stop
Can result in tumors
How do you mutate the receptor
By changing Y1 (or 2/3) to alanine
What does alanine do in the mutated receptor
Will stop the phosphate from binding to that place
What is de function of mutating a receptor
You can find out which protein bound to phosphate does what
There are different kinds of mutations in de tyrosine receptor cascade but for what reason were they made
To figure out the order of the proteins, what activates what
