tyrosine kinase signalling Flashcards
can receptors act as catalysts and amplifiers
yes
can signalling pathways diverge and converge
yes
what does convergence allow
signal integration and coordination
what does sperating activation and deactivation do
enables regualtion by fine tuning of signal size and timing
what is allostery
ability of a molecule to alter conformation of target protein when it binds non covelantly
which pathway is conserved from yeast to man
ERK or MAPK pathway
what pathways enable adaptive and stress sensitive reponses
JNK and p38 MAPK pathways
what are the functions of receptor tyrosine kinase regions
extracellular-ligand binding, transmembrane- membrane anchor, juxtamembrane-positiv /negative regulation, tyrosine kinase-catalytic, c-terminal-signal regulation.
what does RTK ligna dbinding promote
receptor oligomerisation and autophopshorylation
what is EGFR dimerisation mediated by
receptors
how does insulin receptor activation lead to IRS recuitment
disulphide linked heterotetramer of 2 alpha and beta subunits. alpha unit inhibits beta unit kinase activity in absence of insulin
what does recruitment of RTK into clusters do
increases phosphorylation efficeincy and switching on signalling platforms
what are modular interaction domains essential for
signal transduction
what do adaptor proteins exclusively consist of
binding domains no intrinsic enzyme activity.
what do phosphorylated tyrosine residues bind to
proteins with Src homology 2 domains
