lecture 5

Question 1

what is pinocytosis

Answer 1

small all particles taken up into small vesicle fuse with lysosomes. use a lot of ATP.

Question 2

describe how the transferrin receptor works

Answer 2

bind transferrin+ iron-import-internalise complex by RME or CDE

Question 3

what is VSG-G

Answer 3

membrane glycoprotein

Question 4

how can you study secretory pathway

Answer 4

sensitive VSV-G can be turned on or off, follow it by changing temp. can also follow modifications.

Question 5

are ER resident proteins sensitive to Endo-D cleavage

Answer 5

no because they are not trimmed

Question 6

which GTPase controls COPI and clathrin

Answer 6

ARF1

Question 7

which GTPase controls COPII

Answer 7

SAR1

Question 8

what is COPII made up off

Answer 8

Sar1, Sec23, Sec24

Question 9

what are R-SNARES

Answer 9

v-SNARES contribute arginine residue e.g: synaptobrevin

Question 10

what are Q-SNARES

Answer 10

t-SNARES contribute glutamine residue e.g: syntaxin and SNAP-25

Question 11

what does VEGFR2 respond to

Answer 11

VEGF-A and VEGF-C

Question 12

what is VEGFR2 targeted by

Answer 12

E2 ubiquitin enzymes

Question 13

what does VEGF-A stimulate

Answer 13

activation and increase of endocytosis