Tyrosine Kinase Receptors Flashcards
1
Q
what is a tyrosine kinase receptor shaped like?
A
A shrimp embedded in the membrane
2
Q
are tyrosine kinase receptors active when they don’t have ligands bound to them?
A
no
3
Q
how does the shape of the tyrosine kinase receptor change once a ligand binds
A
‘autophosphorylation’
the shrimp tails of the receptor become phosphorylated, flip ‘out’, allowing the binding site to open and start phosphorylating target proteins
4
Q
what hormone is tyrosine kinase receptor involved with?
A
insulin
5
Q
what is the ultimate result of the phosphorylation cascade perpetuated by the tyrosine kinase receptor?
A
activation of kinase b and kinase c (which go on to phosphorylate more/other things/proteins)
