Typical antipsychotics

Question 1

What are the typical anti-psychotics with high potency ( Less doe for good therapeutic effect) for treating schizophrenia ?

Answer 1

Haloperidole , Trifluoperazine, and Fluphenazine.

Question 2

What are the low potency typical anti-psychotics for treating schizophrenia ?

Answer 2

Thioridazine and chlorpromazine.

Question 3

How does typical anti-psychotics work in schizophrenia ?

Answer 3

They inhibit D2 receptors in both the mesolimbic and mesocortical pathway. Inhibition of mesolimbic pathway dopamine receptors alleviates positive symptoms. Whereas inhibition of D2 receptors in mesocortical pathway worsen the negative symptoms.

Question 4

What are the other conditions treated using typical anti-psychotics ?

Answer 4

• Psychosis and delirium
• Bipolar disorder and OCD
• Tourrent syndrome and Huntington’s disease.

Question 5

What are the side effects of typical anti-psychotics ?

Answer 5

• Inhibition of tublo-infendibular pathway leading to hyperprolactenemia and related symptoms.
• EPS due to inhibition of nigrostriatal dopamine receptors. ( hours to days)
• Occulogyric crisis (hours to days)
• Akathesia ( days to months)
• Psuedoparkinsonism ( Days to months)
• Tardive dyskinesia ( Months to years)

Question 6

What is the most dangerous side effect of typical anti-psychotics ?

Answer 6

Neuroleptic malignant syndrome.

Question 7

What is the key clinical differentiator of serotonin syndrome from neuroleptic malignant syndrome ?

Answer 7

In serotonin syndrome there is hyper reflexia and dilated pupils. Whereas in neuroleptic malignant syndrome there is hyporeflexia and normal pupils.

Question 8

Link to osmosis typical anti-psychotics

Answer 8

https://www.osmosis.org/learn/Typical_antipsychotics?from=/pa/foundational-sciences/pharmacology-and-pharmacotherapeutics/psychiatry-behavioral-science/antipsychotics