HIV drugs

Question 1

HIV drugs map

Answer 1

https://www.cell.com/cms/attachment/6ea86ef2-63fe-4285-a32a-3b1e025569b5/gr1.jpg

https://www.cell.com/cms/attachment/614450/4945048/gr1.jpg

Question 2

side effects of NRTIs

Answer 2

https://www.google.com/url?sa=i&url=https%3A%2F%2Fquizlet.com%2F104764038%2Fhivaids-flash-cards%2F&psig=AOvVaw23_NAq87Mhbxx4-ekvOdOr&ust=1720172659376000&source=images&cd=vfe&opi=89978449&ved=0CBEQjRxqFwoTCLiQgeCMjYcDFQAAAAAdAAAAABA1

Question 3

Unique side effects of NRTIs

Answer 3

https://image.slidesharecdn.com/antiretroviraltherapydrugsmechanismofactionadverseeffects2007-090806113610-phpapp02/85/rugs-Mechanism-Of-Action-Adverse-Effects-2007-36-320.jpg

Question 4

HART therapy regimens

Answer 4

https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41569-019-0219-9&psig=AOvVaw0TayeVZfcufBPRZDnvY2y-&ust=1720173655772000&source=images&cd=vfe&opi=89978449&ved=0CBEQjRxqFwoTCOCHsbGQjYcDFQAAAAAdAAAAABAQ

Question 5

MOA of NRTI ?

Answer 5

These are pro-drugs converted to their active form intracellularly by the cellular kinases.NRTIs lack a 3’-hydroxyl group at the 2’-deoxyribosyl moiety. This prevents the formation of a 3’-5’-phosphodiester bond in growing DNA chains which prevent replication of the virus.

Question 6

MOA of NNRTIs?

Answer 6

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are the second class of reverse transcriptase inhibitors. The primary mechanism of action is through the binding of the NNRTI to the reverse transcriptase and the creation of a hydrophobic pocket proximal to the active site. This pocket creates a new spatial configuration of the substrate-binding site to reduce the overall polymerase activity. By creating a different configuration, DNA synthesis becomes slowed overall. Because of the non-competitive inhibitor action of NNRTI, it is not effective against HIV-2 reverse transcriptase