Typical Anti-psychotics (exam 2)

Question 1

Chlorpromazine (thorazine)

Answer 1

-phenothiazide
-aliphatic
-fall in-between for potency and side effects (extra-pyramidal/ANS/sedation)
TOX:
-pigmented cornea (whirl), stellate lens, photosensitivity (rash)
-extrapyramidal issues: Parkinsonism, tardive dyskinesia, elevated prolactin,
anti-muscarinic, anti-adrenergic,

Question 2

Trifluoperazine (stelazine)

Answer 2

-phenothiazide
-piperazine
-most potent
-most likely to cause extra-pyramidal effects
-least likely to cause sedation/ANS effect
-TOX:
-extrapyramidal issues: Parkinsonism, tardive dyskinesia, elevated prolactin,
anti-muscarinic, anti-adrenergic,

Question 3

Thioridazine (mellaril)

Answer 3

-phenothiazide
-piperadine
-least potent
-more likely to cause sedation and ANS effects; acts like antimuscarinic
-low likelihood of extra-pyramidal effect
TOX:
-pigmentation of retina
-extrapyramidal issues: Parkinsonism, tardive dyskinesia, elevated prolactin,
anti-muscarinic, anti-adrenergic,

Question 4

Haloperidol (Haldol)

Answer 4

-butyrophenone
-similar to trifluoperazine:
-potent, high risk to cause extrapyramidal effects and low likelihood of sedation/ANS effect
TOX:
-HIGH RISK extrapyramidal issues: Parkinsonism, tardive dyskinesia, elevated prolactin,
anti-muscarinic, anti-adrenergic,

Question 5

Promethazine (phenergan)

Answer 5

• anti-psychotic that also has anti-histamine effects

- used as an anti-motion sickness medication