Alzheimer's and Parkinson's (exam 2)

Question 1

Cognex
Aricept
Exelon

Answer 1

Reverse cholinesterase inhibitors

side effects related to increased cholingergic activity

Question 2

Memantine (namenda)

Answer 2

block NDMA receptor, decreasing Ca++ influx
acts to slow nerve damage
USES: low tension glaucoma

Question 3

Levodopa

Answer 3

• first line treatment, success decreases with chronic use
• On-off effect: patients can suddenly become frozen in chair, due to flucutations in levodopa blood levels
• dyskinesis also can occur

Question 4

Sinemet

Answer 4

• levodopa combined with carbidopa (MAO inhibitor)

- acts to leave more dopamine for the brain

Question 5

Entacapone

Answer 5

• found in stalevo
• acts to inhibit catechol-O-methyl-transferase
• increases levodopa half life

Question 6

Selegiline (eldepryl)

Answer 6

selective MAO B inhibitor; decreases neuronal degradation

can cause hypertensive crisis w/ tyramine

Question 7

Bromocriptine

Ropinirole

Answer 7

dopamine D2 agonists

Question 8

Benztropine (Cogentin)

Answer 8

-anti-muscarinic that can help relieve symptoms associated with excess ACh
(bring the ACh levels down to balance depleted DA levels of Parkinson)