Atypical Anti-psychotics (exam 2)

Question 1

Clozapine (clozaril)

Answer 1

• Blocks D4, in addition to D2
• lowest extrapyramidal toxicity of all antipsychotics
• may cause agranulocytosis (high fatality)
• weight gain, sedation, tachycardia, hypotension

Question 2

Risperidone (risperdal)

Answer 2

-higher chance of extrapyramidal effects, but no agranulocytosis

Question 3

Olanzapine (zyprexa)

Answer 3

• less chance of extrapyramidal effects or elevated prolactin, low chance of agranulocytosis
• weight gain common, as is sedation

Question 4

Quetiapine (seroquel)

Answer 4

• anti-adrenergic effects
• larger risk of tachycardia and hypotension
• weight gain

Question 5

Aripiprazole (abilify)

Answer 5

• partial agonist activity for D2 and 5HT1A receptors

- less likely cause of weight gain