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PharCare > Typhoid Fever > Flashcards

Typhoid Fever Flashcards

1
Q

Synonyms of Typhoid Fever

A
  • Enteric Fever
  • Salmonellosis
  • Gastric Fever
  • Pathogenic Fever
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2
Q

Causative agent of typhoid fever

A

Salmonella typhi

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3
Q

Non spore-forming, facultative anaerobic bacilli, motile, non-lactose forming; chemoorganotroph

A

Salmonella typhi

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4
Q

Antigens of Salmonella typhi

A

O, H, Vi Antigens

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5
Q

Severe gastroenteritis accompanied by a high fever

A

Typhoid

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6
Q

Cause of typhus fever

A 
Rickettsiae typhi (fleas)
Rickettsiae prowazekii (body lice)
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7
Q

Family of salmonella typhi

A

Enterobacteriaceae

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8
Q

Where does the typhoid organism pass through to reach the small intestine

A

Pylorus

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9
Q

Salmonella typhi penetrates mucosal epithelium via:

A
  • Microfold cells

* Enterocytes

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10
Q

Where Samonella typhi elicit an influx of macrophages

A

Lamina propria

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11
Q

Incubation period of Salmonella typhi

A

8-14 days

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12
Q

Induce inflammatory reaction

A

Proinflammatory cytokines

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13
Q

How typhoid pathogen penetrate the intestinal epithelium

A

Peyer’s Patches

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14
Q

Virulence factor responsible for the multiplication of Salmonella

A

Invasins

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15
Q

Virulence factor responsible for fever production of Salmonella

A

Lipid A Endotoxin

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16
Q

Virulence factor that causes cellular invasion of intestinal cells; produce ulcers (by Salmonella)

A

Cytotoxins

17
Q

Virulence Factor that increases secretion of sodium

A

Heat-Stable Exotoxin

18
Q

Virulence Factor that increases secretion of Chloride

A

Heat-Labile Exotoxins

19
Q

Characteristic of stool of those infected w/ typhoid fever

A

Greenish Pea Soup

20
Q

Slow pulse

A

Dicrotic

21
Q

Rose Spots

A

Exanthem

22
Q

Signs and symptoms of Typhoid Fever

A

Rose Spots, Diarrhea, Splenomegaly

23
Q

Adults: Constipation or diarrhea

A

Constipation

24
Q

Most common method of diagnosis of Typhoid Fever

A

Blood Culture

25
Q

Detects agglutinating of antibodies against the O and H antigens of S. typhi

A

Widal Test

26
Q

Detects IgM to the 0:9 Antigen

A

IDL Tubex

27
Q

Detects both IgM and IgG

A

Typhidot Assay

28
Q

Major complications of Typhoid Fever

A

Intestinal Perforations

Intestinal Hemorrhage

29
Q

Two Vaccines for Typhoid Fever

A

Vi Polysaccharide

Live Oral Vaccine Ty21a

30
Q

Antigen that is a heat-labile flagella; protein structure

A

H Antigen

31
Q

Heat stable antigen; outer membrane; production of fever; somatic

A

O Antigen

32
Q

Outer shell envelope; inhibits phagocytosis by interfering w/ actions of complement systems; increase virulence

A

Vi Antigen

33
Q

4 Stages of Typhoid Fever:

A
  • Temp Rising
  • High Fever
  • Complications
  • Defervescence
34
Q

1st Drug of Choice for Typhoid Fever

A

Chloramphenicol

35
Q

Drug with the risk of irreversible bone marrow aplasia

A

Chloramphenicol

36
Q

Adjunctive therapy

A

Dexamethasone

37
Q

Drug that lowers the likelihood of relapse

A

Oral amoxicillin

38
Q

Other drugs (first-line of antibiotics)

A

Ampicillin, Trimethoprim-Sulfamethoxazole

39
Q

Spleen

A

Lymphoid Tissue

PharCare (5 decks)

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