Types of Necrosis Flashcards

1
Q

Coagulative Necrosis

A

Seen in ischemia/infarcet in most tissues (except brain)

Due to ischemia or infarction; proteins denature then enzymatic degredation

Cell outlines preserved but nuclei disappear; increased cytoplasmic binding of eosin dye

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2
Q

Liquefactive necrosis

A

Seen in bacterial abcess, brain infarcts

Due to: neutrophils release lysosomal enzymes that digest the tissue; enzymatic degradation first, then proteins denature

Histology:

early: cellular debris and macrophages

Late: cystic spaces and cavitation(brain) Neutrophils and cell debris seen with bacterial infection

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3
Q

Caseous Necrosis

A

Seen in TB, systematic fungi, nocardia

Macrophages wall off the infecting microorganism -> granular debris

Histology: Feagmented cells and debris surrounded by lymphocytes and macrophages

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4
Q

Fat necrosis

A

Seen in: enzymatic acute pancreatitis (saponification of peripancreatic fat) nonenzymatic traumatic (eg breast tissue injury)

Damaged cells release lipase to break down triglycerides , liberating fatty acids to bind calcium-> saponifiction

Histology: outlines of dead fat cells without peripheral nuclei; saponification of fat (combined with (Ca2+) appears dark blue on Hand E

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5
Q

Fibrinoid necrosis

A

Seen in immune reactions in vessels, preeclampsia, malignant HTN

Immune complexes combine with fibrin -> vessel wall damage (type III hypertensivity rxn)

Vessel walls are thick and pink

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6
Q

Gangenous necrosis

A

Seen in distal extremity and GI tract, after chronic ischemia

Dry: ischemia

wet: superinfection

Histology:

Dry:coagulatice

wet: liquefactive superimposed on coagulative

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7
Q
A

Coagulative necrosis

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8
Q
A

Liquefactive necrosis

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9
Q
A

Caseous Necrosis

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10
Q
A

Fat necrosis

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11
Q
A

Fibrinoid necrosis

vessel walls are thick and pink

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12
Q
A

Gangrenous necrosis

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