Types of DNA damage Flashcards
1
Q
what are common types of errors?
A
spontaneous mutations called depurination and deamination
2
Q
what is depurination?
A
loss of A or G
3
Q
what is Deamination?
A
Change of C to U
4
Q
What are induced types of DNA damage?
A
Radiation and chemicals
5
Q
what does radiation do?
A
produces thymine dimers, sunlight can cause this
6
Q
what do chemical errors do?
A
intercalate (insert) into DNA strands
7
Q
how many proteins are devoted to DNA repair?
A
50
8
Q
what are the basic steps for repair?
A
- endonuclease excises damaged DNA
- DNA polymerase fills in the gap
- Nick sealed by DNA ligase