Types of diabetes

Question 1

MODY 2

Answer 1

patient looks like they have diabetes
follows an autosomal dominant pattern of inheritence
mild in nature
little evidence of worsening glucose over time

a mutation in the glucokinase gene, effectively the glucose sensor

the blood glucose level is ‘reset’ at a higher level which is between 6-8mmol/l and usually managed by diet and complications are rare except in pregnancy.

Question 2

MODY 3 hepatic nuclear factor 1 (HNF-1 alpha)

Answer 2

most common type of MODY
strong family history of diabetes
can be misdiagnosed of type 1 but patients will be autoantibody negative at diagnosis

Question 3

MODY 1 HNF-4 alpha

Answer 3

similar to HNF-1 alpha but much less common

Question 4

MODY 5 HNF4-alpha

Answer 4

very rare

strong association with kidney problems (renal cysts0

Question 5

LADA - latent auto immune diabetes in daults

Answer 5

a form of type I that presents later in life

insulinopaenia
thin 
losing weight
thirst and tierdness
very high random glucose and autoantibodies

Question 6

imapired fasting hyperglycaemia

Answer 6

fasting blood glucose 6.2mmol/l

do an OGGT

high risk of developing type II but can be reversed.