Type III Hypersensitivity Flashcards
Type III hypersensitivity is also referred to as:
A) Autoimmune hypersensitivity
B) Delayed hypersensitivity
C) Complex-mediated hypersensitivity
D) Immediate hypersensitivity
C) Complex-mediated hypersensitivity
In Type III hypersensitivity reactions, which antibodies react with soluble antigens to form small complexes that precipitate in the tissues and activate complement?
A) IgA antibodies
B) IgE antibodies
C) IgG or IgM antibodies
D) IgD antibodies
C) IgG or IgM antibodies
Type III hypersensitivity results in an inflammatory response that causes injury to the tissues. Which of the following immune cells play a key role in this process?
A) Neutrophils
B) T lymphocytes
C) B lymphocytes
D) Natural killer cells
A) Neutrophils
Which of the following is a classic example of Type III hypersensitivity?
A) Serum sickness
B) Immediate
C) Lupus
D) None of the above
A) Serum sickness
In Type III hypersensitivity reactions, the immune response is typically:
A) Immediate
B) Delayed
C) Chronic
D) None of the above
B) Delayed
Which autoimmune disease is associated with Type III hypersensitivity reactions?
A) Serum sickness
B) Immediate
C) Lupus
D) None of the above
C) Lupus
Which of the following statements accurately describes the role of exocytosis in cellular processes?
A) Exocytosis is primarily involved in engulfing large target cells for phagocytosis.
B) Exocytosis releases granule and lysosome contents when target cells are small and easily engulfed.
C) Exocytosis releases granule and lysosome contents when target cells are large and cannot be engulfed.
D) Exocytosis plays no significant role in cellular processes.
C) Exocytosis releases granule and lysosome contents when target cells are large and cannot be engulfed.
Which of the following best describes the Arthus reaction?
A) An allergic reaction triggered by the ingestion of an allergenic food.
B) An autoimmune response involving the production of autoantibodies.
C) An intradermal injection of antigen into a rabbit, named after Maurice Arthus in 1903.
D) A type of hypersensitivity reaction caused by airborne allergens.
C) An intradermal injection of antigen into a rabbit, named after Maurice Arthus in 1903.
What characterizes the Arthus reaction?
A) The formation of immune complexes that deposit in small dermal blood vessels.
B) Complement fixation and attraction of neutrophils.
C) Activation of mast cells to release permeability factors C3a and C5a.
D) Occurs following booster injections with tetanus, diphtheria, or measles vaccines.
A) The formation of immune complexes that deposit in small dermal blood vessels.
What is the role of complement in the Arthus reaction?
A) Attraction of neutrophils.
B) Activation of mast cells to release permeability factors.
C) Formation of immune complexes in small dermal blood vessels.
D) None of the above.
A) Attraction of neutrophils.
Which complement factors are involved in activating mast cells to release permeability factors during the Arthus reaction?
A) C3a and C5a.
B) C1q and C2.
C) C4 and C6.
D) C7 and C8.
A) C3a and C5a.
In what context can the Arthus reaction occur?
A) During an allergic response to pollen.
B) After consuming contaminated food.
C) Following booster injections with tetanus, diphtheria, or measles vaccines.
D) As a result of chronic stress.
C) Following booster injections with tetanus, diphtheria, or measles vaccines.
Which infections were treated with horse antiserums that led to the development of serum sickness?
A) Measles and mumps
B) Diphtheria, tetanus, and pneumonia
C) Influenza and COVID-19
D) Tuberculosis and hepatitis
B) Diphtheria, tetanus, and pneumonia
Autoimmune disease of type 3 - SLE and rheumatoid arthritis (RA) is typically diagnosed using which of the following diagnostic techniques?
A) Indirect immunofluorescence
B) Enzyme-linked immunosorbent assay
C) Fluorescent microsphere multiplex immunoassays
D) All of the above
D) All of the above
Which of the following statements regarding rheumatoid factor (RF) is correct?
A) RF is an antigen produced by IgG.
B) RF can be detected by Western blot analysis.
C) RF can be detected by latex agglutination, nephelometry, or other immunoassays.
D) RF is an enzyme produced in response to inflammation.
C) RF can be detected by latex agglutination, nephelometry, or other immunoassays.
