Type 1 hypersensitivity reactions

Question 1

Which antibody is involved in type 1 hypersensitivity reaction?

Answer 1

IgE

Question 2

What are other names for a type 1 hypersensitivity reaction?

Answer 2

IgE-mediated
Immediate sensitivity

Question 3

What type of reactions are most allergens?

Answer 3

Type 1 hypersensitivities

Question 4

Where do IgE antibodies bind?

Answer 4

surface of mast cells

Question 5

What happens during a second exposure?

Answer 5

Antigens recognise the antibody. the mast cells degranulate and release pro-inflammatory mediators

Question 6

What do pro-inflammatory mediators do?

Answer 6

create the response seen during an allergic reaction

Question 7

What is an example of a pro-inflammatory mediator?

Answer 7

Histamine

Question 8

What does histamine do?

Answer 8

binds to H1 receptors
Causes smooth muscle contraction - in the airways, causing difficulty in breathing

Blood vessel dilation - increasing blood vessel permeability = oedema and urticaria