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Immunuology > Tutorial multi choice questions > Flashcards

Tutorial multi choice questions Flashcards

1
Q

what does the mononuclear phagocyte include and not include?

A

Include: monocytes, kupffer cells, kidney mesangial cells and lymph node medullary macrophages
NOT: endothelial cells

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2
Q

what does the membrane attach complex consist of?

A

C5b,6,7,8,9

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3
Q

what does C3b do?

A

opsonises bacteria

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4
Q

what compliment component is strongly chemotactic for neutrophils?

A

C5a

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5
Q

what initial complement component is activated by complement-fixing antibodies?

A

C1q

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6
Q

what complement component does the classical and alternative pathways meet?

A

C3

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7
Q

when does clonal selection occur?

A

when antigen is encountered by T cells

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8
Q

what does plasma cells secrete?

A

antibody of a single speciality related to that on the surface of the parent B cell

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9
Q

what did Edward Jenner use to vaccinate against smallpox?

A

cowpox

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10
Q

what do T cell surface receptors for antigen partly recognise?

A

MHC

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11
Q

what does an immune response against grass pollen involve?

A

hypersensitive reaction

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12
Q

why are secondary antibody response better?

A

stronger and faster

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13
Q

what cell type produces antibodies?

A

plasma cells

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14
Q

what provides protection against micro-organisms inside cells?

A

T cells

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15
Q

what is the basic immunoglobulin unit composed of?

A

2 identical heavy and 2 identical light chains

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16
Q

what does a Fab fragment do?

A

binds antigen

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17
Q

what are the complementary determining regions concerned in?

A

antigen recognition

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18
Q

what gene cluster does not contribute to antigen binding?

A

CL

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19
Q

what is not true of IgG?

A

appears early in the primary immune response

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20
Q

what is IgA in seromucous secretions?

A

dimeric

21
Q

what does IgE bind strongly to?

A

mast cells

22
Q

what is the Fab region of an immunoglobulin responsible for?

A

binding to antigen

23
Q

what is the main immunoglobulin in seromucus secretions defending the external body surfaces?

A

IgA

24
Q

what is the first immunoglobulin heavy chain class expressed on the surface of B cells?

A

IgM

25
Q

what is expression of MHC genes?

A

codominant

26
Q

what is a T cell receptor for antigen?

A

heterodimer

27
Q

what does each chain of the T cell receptor consist of?

A

two immunoglobulin-like domains

28
Q

what are MHC class II molecules found on?

A

B cells- dendritic cells and macrophages

29
Q

what is an antigen moiety on an antigen-presenting cell recognised by the T-cell receptor?

A

processed (peptide) antigen plus MHC

30
Q

what is an epitope?

A

the area on an antigen which contacts antibody

31
Q

what does binding of antigen to antibody depend on?

A

spatial complementarity

32
Q

what do T cell receptors recognise?

A

linear antigen peptide in the MHC groove

33
Q

Name a primary lymphoid organ.

A

thymus

34
Q

what is expression of a CD8 a characteristic of?

A

cytotoxic T lymphocytes

35
Q

what immunoglobulin class crosses the placenta to provide a high level of passive immunity at birth?

A

IgG

36
Q

what are extracellular bacteria optimally killed by?

A

macrophages plus antibody plus complement

37
Q

what are the mucosal surfaces initially protected by?

A

secretory IgA

38
Q

what is the protection against worm infections infestations particularly associated with an increase in?

A

IgE

39
Q

what disease has been completely eradicated world-wide?

A

smallpox

40
Q

what do defects in neutrophil NADPH oxidase produce?

A

chronic granulomatous disease

41
Q

what does HIV bind to?

A

CD4

42
Q

what can a type I hypersensitivity be blocked by?

A

sodium cromoglycate

43
Q

which type pf hypersensitivity cannot be transferred with serum antibody?

A

Type IV

44
Q

what does rhesus haemolytic disease of the newborn involve?

A

antibody to cell surfaces

45
Q

what is type IV hypersensitivity often referred to as?

A

delayed

46
Q

Name a non-organ-specific (systemic) autoimmune disease.

A

systemic lupus erythematosus

47
Q

what can pernicious anaemia be treated with?

A

Vitamin B12

48
Q

what is a therapeutic approach in rheumatoid arthritis?

A

inhibit TNF alpha activity

Immunuology (10 decks)

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