Turning Point Sessions Flashcards
1
Q
A shift of an oxygen dissociation binding curve to the right indicates which of the following?
A. Decreased affinity of Hgb for oxygen
B. Decreased dissociation of oxygen to Hgb
C. Decreased T state of Hgb
D. Increased affinity of Hgb for oxygen
E. Increased binding of oxygen to Hgb
F. Increased R state of Hgb
A
A
2
Q
Which of the following would result in a shift to the right of an oxygen dissociation binding curve? A. Decrease in CO2 concentration B. Decrease in H+ concentration C. Increase in 2,3-BPG concentration D. Increase in CO concentration E. Increase in Fe(2+) concentration
A
C
3
Q
Which one of the following best describes carbaminohemoglobin? A. CO2 carried in the blood bound to Hgb B. Hgb in the R state C. Hgb with 2,3-BPG bound to it D. Hgb with CO bound to it E. Oxidation of Fe(2+) to Fe(3+)
A
A
4
Q
Which of the following best describes when two molecules of CO are bound to Hgb? Molecules of O2 Bound/Curve Shift A. 2/left B. 2/right C. 4/left D. 4/right
A
A
5
Q
Which of the following best describes why HbF allows the fetus to get oxygen from the mother?
A. HbF cannot bind CO
B. HgF has a lower binding affinity for 2,3-BPG
C. HgF has higher anhydrous Fe(3+)
D. HgF is not affected by pH
E. Lower pO2 on fetus side of placenta drives diffusion of O2 across placenta
A
B
6
Q
Which one of the following describes hemoglobin with a glutamic acid to lysine amino acid change? A. Beta-thalassemia B. Hemoglobin C Disease C. Hemoglobin H Disease D. Methemoglobinemia E. Sickle Cell Disease
A
B
7
Q
Which of the following best describes the mechanism of the drug Imara? A. Decrease 2,3-BPG B. Decrease HbS C. Increase HbA2 D. Increase HbF E. Reduce Fe(3+) to Fe(2+)
A
D
8
Q
In hereditary persistence of fetal hemoglobin, which of the following would be elevated? A. alpha2-beta2 B. alpha2-delta2 C. alpha2-gamma2 D. epsilon2-zeta2
A
C
9
Q
In a patient with a NADH-cytochrome b5 reductase deficiency, which one of the following would most likely be increased? A. 2,3-BPG B. Fe(3+) C. HbA2 D. HbF E. HbS
A
B
10
Q
A patient with the inability to synthesize the beta-globin protein has which of the following? A. beta-thalassemia minor B. Cooley anemia C. Hemoglobin H Disease D. Methemoglobinemia E. Sickle Cell Disease
A
B
11
Q
A patient with a defect in 3 of the 4 alpha-globin genes has which of the following? A. beta-thalassemia minor B. Cooley anemia C. Hemoglobin H Disease D. Methemoglobinemia E. Sickle Cell Disease
A
C
12
Q
Which of the following immunoglobins is most abundant in plasma? A. IgA B. IgD C. IgE D. IgG E. IgM
A
D
13
Q
Which one of the following is the chain arrangement for IgM? A. (a2k2)2, (a2l2)2 B. d2k2, d2l2 C. e2k2, e2l2 D. g2k2, g2l2 E. (m2k2)5, (m2l2)5
A
E
14
Q
Which one of the following structures determines the type of immunoglobulin? A. Antigen binding site B. Constant domain C. Heavy Chain D. Light Chain E. Papain Cleavage Site
A
C
15
Q
Which one of the following would have hypervariability in its amino acid sequence? A. Antigen binding site B. Constant domain C. Heavy Chain D. Light Chain E. Papain Cleavage Site
A
A
16
Q
Which of the following would best quantitate the amount of albumin in our plasma? A. ELISA B. Chromatin immunoprecipitation (ChIP) C. Immunoprecipitation D. Monoclonal Antibodies E. Polyclonal Antibodies
A
A
17
Q
Which of the following would best demonstrate the size of a protein? A. ELISA B. Chromatin immunoprecipitation (ChIP) C. Immunoprecipitation D. Monoclonal Antibodies E. Polyclonal Antibodies
A
C
18
Q
Which one of the following would best indicate a fully human immunotherapy? A. -Momab B. -Mumab C. Polyclonal Antibodies D. -Ximab E. -Zumab
A
B
