Cell Death

Question 1

Cell Death
Programmed:
[1] - cell suicide programmed by itself
[2] self-eating catabolic process involving lysosome
Non-Programmed:
[3] - death caused by trauma or toxins

Answer 1

[1] Apoptosis (Type I)
[2] Autophagy (Type II)
[3] Necrosis (Type III)

Question 2

DNA Fragmentation of a [1] Cell:
DNA ladder
nucleases fragment DNA into small, defined nucleosome sized fragments

Answer 2

[1] Apoptosis

Question 3

DNA Fragmentation of a [1] Cell:

one large smear going across the plate

Answer 3

[1] Necrotic

Question 4

[1] Cell Death Pathway:
induced by cell injury (growth factor withdrawal, DNA damage, protein misfolding)
the [2] family stimulates the release of [3] from the mitochondria which leads to the activation of caspases

Answer 4

[1] Intrinsic (Mitochondrial)
[2] Bcl-2
[3] Cytochrome C
[4]

Question 5

[1] Cell Death Pathway:
induced by receptor-ligand interactions
this receptor-ligand is usually [2]
leads to the activation of caspases

Answer 5

[1] Extrinsic (Death Receptor)

[2] Fas / TNF receptor