tumour suppressor genes

Question 1

Tumour suppressor genes restrict or repress cellular proliferation in normal cells. Their inactivation through mutation or germ line incorporation is implicated in renal, colonic, breast, bladder and many other cancers. One of the best known tumour suppressor genes is p53. p53 gene offers protection by causing apoptosis of damaged cells. Other well known genes include BRCA 1 and 2.

loss of function of these results in what

Answer 1

increased risk of cancer

Tumour suppressor genes - loss of function results in an increased risk of cancer

Question 2

gain of function results in an increased risk of cancer

what describing

Answer 2

oncogenes

Question 3

p53 associated with what cancers

Answer 3

Common to many cancers, Li-Fraumeni syndrome

Question 4

APC

Answer 4

colorectal cancer

Question 5

BRCA1and2

Answer 5

Breast and ovarian cancer

Question 6

NF1

Answer 6

neurofibromatosis

Question 7

Rb

Answer 7

retinoblastoma

Question 8

WT1

Answer 8

wilms tumour

Question 9

Multiple tumor suppressor 1 (MTS-1, p16)

Answer 9

melanoma