Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

SBCP Biochemistry > Tumour Markers > Flashcards

Tumour Markers Flashcards

1
Q

What does lactate dehydrogenase indicate?

A

Non specific marker for haematological malignancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What does raised ALP indicate?

A

Non specific marker for bone cancer/mets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What does raised total protein indicate?

A

Non specific marker for myeloma, or Waldenstrom’s macroglobulinaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What does raised Ferritin indicate?

A

Non specific marker for renal cell carcinoma, myeloid leukaemia, HCC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

AFP as a marker? (oncofetal antigen)

A

HCC screening

Ovarian/testes cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

CEA as a marker? (oncofetal antigen)

A

Colorectal carcinoma

Also:
Lung, stomach, ovarian, pancreas, breast

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

bHCG as a marker? (4) (hormone)

A

Pregnacny
Choriocarcinoma
Non-seminomas
Trophoblastic tumours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Metanephrines as a marker?

A

Phaechromocytoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Calcitonin as a marker?

A

Medullary carcinoma (thyroid)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

IGF-1 as a marker?

A

Pituitary malignancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

CA 19-9 as a marker? (glycoprotein)

A

Pancreatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

CA 125 as a marker? (glycoprotein)

A

Ovarian

Also:
Breast
Pancreas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

PSA as a marker? (enzyme)

A

Prostate malignancy (non specific)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Neurone specific enolase as a marker? (enzyme) (2)

A 
SCLC
Neuroendocrine tumours (gastrinoma(
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Squamous cell carcinoma antigen (SCC-A) as a marker?

A

SCC of lung, uterus, cervix, head and neck

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Igs as a marker?

A

Raised in myeloma

17
Q

Markers for multiple myeloma?

A

Bence Jones protein
Free light chains
B2 micoglobulin is used to measure the mass of tumour in followup

18
Q

Markers for neuroendocrine tumours? (recognise)

A

Serotonin, 5 hydroxy tryptamine
Catecholemines
Chromogranin A

19
Q

Screening programme for colorectal cancer?

A

FIT testing every 2 years for 60-74 yr olds

20
Q

Disadvantage of CA125 in ovarian screening?

A

Normal in 30% of women with stage 5 ovarian cancer

Raised in many other conditions

But may be useful with pelvic USS in women over 50 with symptoms

Gives a lead time of 4 months for detection of cancer recurrence which is useful

21
Q

Markers useful for non seminomas

A

AFP with HCG

22
Q

Markers useful for seminoma tumours

A

HCG with LDH

23
Q

Which non malignant conditions raise AFP?

A

Cirrhosis, hepatitis, telangiectasia, pregnanct

24
Q

Which marker is used to test for recurrence in colorectal cancer?

A

CEA

Can also be raised in smoking, other tumours, or IBD, pancreatitis and liver disease

25
Q

Which benign conditions can raise CA 19-9?

A

Pneumonia, hepatobiliary disease, renal failure

SBCP Biochemistry (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions