BNP Flashcards
1
Q
What produces BNP?
A
Myocardial cells when under stress or stretched
Brain
2
Q
How is BNP produced? (recognise)
A
Prodcued in myocyte as pro-BNP, converted to pre-pro BNP in the cell
3
Q
Name of BNP fragement measured in the circulation?
A
N terminal pro-BNP (inactive)
Can also measure the BNP itself
4
Q
Actions of BNP (3)
A
Vasodilation
Increased urinary sodium excretion
Myocyte growth/fibrosis
(tries to reduce strain on heart)
5
Q
Clearance of BNP (2)
A
Breakdown by neural endopeptidase
Clearance by receptors
6
Q
Uses of BNP monitoring?
A
Diagnosis of heart failure used to rule it out)
Screening for LV dysfunction
Risk stratification in heart failure and ACS
7
Q
What other conditions can BNP be used to assess prognosis? (recognise) (5)
A
Chronic HF Post MI Elderly PE General pop as predictor of 4 yr all cause mortality
