Tumors of the Urethra (Chap 80 12th ed)

Question 1

Which has a better prognosis, proximal or distal anterior proximal urethral cancer (PUC)?

Answer 1

The prognosis of distal anterior male posterior urethral cancer (PUC) is better than that of proximal anterior PUC, which is often
associated with local invasion and distant metastasis.

Question 2

What are the three most common histologies for female urethral cancer

Answer 2

The three most common histologies for female urethral cancer are
urothelial carcinoma, squamous cell carcinoma, and
adenocarcinoma.

Question 3

Which as a worse survival, anterior or posterior urethral cancers?

Answer 3

Compared to anterior urethral cancers, posterior cancers present at a
more advanced stage and are associated with worse survival.

Question 4

What are the predictors of male urethral recurrence after radical cystectomy?

Answer 4

Male urethral recurrence after radical cystectomy is rare, but more
common with prostatic involvement, a positive urethral margin, and
cutaneous diversions.

Question 5

What are the risk factors for female urethral recurrence after radical cystectomy?

Answer 5

The primary risk factors for female urethral recurrences are bladder
neck involvement and a positive urethral margin.

Question 6

How does the decision to do orthotopic neobladder depend on urethral margin status?

Answer 6

Most surgeons will proceed with orthotopic neobladder if an

intraoperative frozen section of the urethral margin is negative.