BPH (143-147 12th ed)

Question 1

What composes the stromal component of the prostate? the epithelial?

Answer 1

stroma: connective tissue, smooth muscle cells, fibroblasts
epithelial: basal cells, intermediate cells, neuroendocrine cells

Question 2

When should testosterone be measured?

Answer 2

Because of the diurnal variation of serum testosterone, to avoid
inconsistency it should be measured in the morning.

Question 3

What is the half-life of testosterone and what is its significance in orchiectomy?

Answer 3

Because the plasma half-life of testosterone is 10 to 20 minutes,
patients who undergo bilateral orchiectomy are functionally castrate
within 1 to 2 hours after surgery.

Question 4

How many of patients who undergo spontaneous AUR progress to surgery? if precipitated?

Answer 4

After spontaneous acute urinary retention (AUR), 15% of patients
will have another episode and three fourths will undergo surgery;
after precipitated AUR, 9% will have another episode and 26% will
undergo surgery.

Question 5

Maximum flow rate in BOO?

Answer 5

<10ml/sec

Question 6

What medications exacerbate LUTS?

Answer 6

Cold medications containing α-sympathomimetics tend to exacerbate
lower urinary tract symptoms by the expected effect on the smooth
muscle of the bladder outlet.

Question 7

What may be a contributing factor brought about by age in male LUTS?

Answer 7

A significant portion of male lower urinary tract symptoms is related
to age-related detrusor dysfunction and other conditions unrelated to
the prostate