Tumors of CV System- Melissa (3) Flashcards
What is a hemangioma?
Where do they occur (2)
- Benign tumor of blood vessels that resemble capillaries
- Occur in skin, subQ tissues, mucous membranes, and internal organs (liver, spleen, kidney)
Describe the gross morphology of a hemangioma:
- Vary in size, elevation, and color (blue-red)
- Blood filled, thin walled capillaries (blanching)
What is a strawberry hemangioma?
By when do they regress?
- Hemangioma found on skin of newborns
- Common; regress by 7yoa
What is a glomus tumor?
What do they look like?
From what type of cells do they originate?
Where are they found?
- PAINFUL, benign vascular tumor
- Small, elevated, red-blue color, firm nodules
- Originates in smooth muscle of glomus body
- Commonly found on tips of fingers and toes
What are glomus bodies?
AV shunts in skin/ soft tissue at tips of fingers and toes; function to conserve heat/ shunt blood proximally when body is cold
Components of glomus tumor (2)
- Branching vascular channels
- Aggregates of glomus cells
List the 4 vascular ectasias.
Are these benign or malignant tumors?
Benign:
- Nevus Flammus
- Port Wine Stain
- Spider Telangiectasia
- Osler Weber Rendu Disease
What is a nevus flames?
Where do they most commonly occur?
What is their prognosis?
Light pink-purple “Birth mark”
- occurs on head and neck
- most fade or regress
What is a port wine stain and with what disease are they associated?
- special type of nevus flames that may thicken and not fade
- associated with Sturge Weber Syndrome
What are the three findings associated with Sturge Weber Syndrome?
Port wine stain in distribution of CN V
Leptomeninges- venous angiomas
CNS- Mental retardation, seizures, hemiplegia, radiopacities in skull
Spider telangectasias:
- Describe the lesion
- Where are they commonly found?
- In what type of patients do these most often occur (2)?
- Benign, radial, pulsatile vascular lesion w/ blanching central core
- Head and neck
- Associated with ^ Estrogen:
1. Preggos
2. Liver failure!
What is Osler-Weber-Rendu Disease?
What is its inheritance pattern?
Symptoms:
“Hereditary Hemorrhagic Telangiectasia”
- AD inheritance
- Dilated capillaries, vv’s in mucous membranes - Lesions are benign, present at birth, and distributed across body in well defined regions
*bleeding everywhere: nose, GI, urine, everywhere!!!
Bacillary Angiomatosis:
What what are these lesions like and what organism causes them?
- Vascular proliferation in immunosuppressed
- Associated with Bartonella infections
4 forms of Kaposi Sarcoma:
- Chronic (older european men)
- Lymphadenopathic (endemic-african children)
- Transplant-associated
- AIDS-Assocated
Describe AIDS Assocated Kaposi Sarcoma:
How common is it?
What is the prognosis?
- # 1 AIDS associated malignancy
- AIDS defining illness
- HAART decreased incidence to under 1%
- Involves lymph nodes, viscera, disseminates widely, but NOT FATAL
Which virus causes AIDS related Kaposi Sarcoma? How does this work?
- KS associated herpesvirus: HHV8
- Tumor progression requires cofactor provided by HIV
Three stages of Kaposi Sarcoma Development: how aggressive are these tumors?
- Patch
- Plaque
- Nodule
* Intermediate grade malignancy*