Tumors

Question 1

What is the most common mesenchymal tumor of the esophagus?

Answer 1

Leiomyoma

Question 2

What is the most common mesenchymal tumor of the GI tract?

Answer 2

GIST

Question 3

What are neuroendocrine cells?

Answer 3

Epithelial cells at the base of crypts

Question 4

Where in the mucosa do NETs develop?

Answer 4

Base, at the mucosa/submucosa jxn

Question 5

Where do neuroepi granules face?

Answer 5

Away from lumen, toward blood

Question 6

Where do paneth cell granules face?

Answer 6

toward lumen , away from blood

Question 7

What is the most common site for extranodal lymphomas?

Answer 7

GI tract (stomach often involved, then sb then colon)

Question 8

What is the differential diagnosis for lymphomatous polyposis?

Answer 8

1. Reactive lymphoid hyperplasia (immunosupp)
2. Mantle zone lymphoma (colon)
3. Follicular lymphoma

Question 9

Translocation of Mantle cell lymphoma

Answer 9

t(11;14), cyclin D1 over exp (BLC-1)

Question 10

Translocation of follicular cell lymphoma

Answer 10

t(14;18) BCL-2 expression

Question 11

Translocation of MALT

Answer 11

t(11;18), Resistance to H pylori therapy

Question 12

Burkitt Lymphoma

Answer 12

t(11;18) c-myc

Question 13

How do you screen from CRC?

Answer 13

1. FOBT (focal occult blood testing)
2. Sigmoidoscopy
3. Colonoscopy
4. Virtual colonoscopy (CT based, can’t detect small polyps)
5. Fecal DNA markers

Question 14

Most common type of biliary tract cancer?

Answer 14

Gallbladder carcinoma