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GI > Autoimmune, PBC, PSC, DILI > Flashcards

Autoimmune, PBC, PSC, DILI Flashcards

1
Q

What is autoimmune hep?

A

Syndrome of progressive hep characterized by loss of tolerance to hepatic autoantigens

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2
Q

What autoabs is characteristic of autoimmune dis?

A

ANA

can see SMA, LP, LKM1 also

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3
Q

What does AIH co-occur with?

A

other autoimmune diseases like thyroid dis, Sicca syndrome

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4
Q

What is histologically characteristic for AIH?

A

lymphoplasmacytic infiltrate

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5
Q

How do you treat AIH?

A

Steroids and azathioprine

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6
Q

What is primary biliary cirrhosis

A

Chronic inflammation and destruction of interlobular and septal bile ducts leading to chronic cholestasis and biliary cirrhosis (maybe)

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7
Q

What autoAb is seen in PBC?

A

AMA

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8
Q

Who gets PBC M or F?

A

F

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9
Q

What lab is elevated in PBC?

A

alk phos (that with AMA is enough to diagnose)

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10
Q

What is PBC histo

A

noncaseating granuloma, inflammation, destruction of intrahepatic ducts, small bile duct disease

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11
Q

How do you treat PBC

A

Ursodiol

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12
Q

What are some side effects to PBC

A
  • pruritus
  • fatigue
  • jaundice
  • xanthelasma
  • vitiligo
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13
Q

What do we do with hypercholes in PBC

A

nothing, TGs arent circulating so its fine

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14
Q

What is primary sclerosing cholangitis?

A

Chronic cholestatic liver disease of unknown etiology characterized by inflammation and fibrosis of biliary tree. Ie large duct disease

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15
Q

Who gets PSC? M or F?

A

M

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16
Q

What ERCP/MRCP finding is consistent with PSC?

A

Beads on a string

17
Q

How do we get PBC?

A

Abnormal presentation of pyruvate dehydrogenase–>biliary epithelial cell death

18
Q

What imaging dont you want to do with PSC?

A

ERCP because ducts are dilated and can cause infection

19
Q

What is PSC associated with ?

A

UC, inc risk of colon cancer

20
Q

Histology of PSC?

A
  • onion skin fibrosis
  • biliary sludge
  • loss of bile ducts
21
Q

What drugs can cause intrinsic DILI? (drug induced liver disease)

A

Acetaminophen and methotrexate

ie predictable with dose etc

22
Q

What drugs can cause idosyncratic DILI?

A

Augmentin, statins

ie unpredictable

GI (12 decks)

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