Liver Path 1

Question 1

What is the toxic metabolite of acetaminophen

Answer 1

NAPQI

Question 2

What enzyme makes the acetamin metab non toxic?

Answer 2

Glutathione

Question 3

What three histologic findings are characteristic of hepatitis?

Answer 3

1. Lymphocytes in portal tract
2. Apoptotic hepatocytes
3. Interface activity (ie inflammation and death)

Question 4

Hep C causes which zone destruction

Answer 4

Zone 1

Question 5

Steatosis causes which zone destruction?

Answer 5

Zone 3

Question 6

What labs are elevated with steatosis?

Answer 6

inc ALT/AST and ALK/GGT

Question 7

What histologic feature characterizes steatohepatitis?

Answer 7

Ballooning degeneration in which ROS mess with hepatocyte

=a fatty liver with hepatocyte death

Question 8

What labs are elevated with cholestasis?

Answer 8

ALT, AST, GGT, ALK, Bilirubin

Question 9

Where is bilirubin usually first seen in cholestasis?

Answer 9

Zone 3

Question 10

What are two histologic findings of cholestasis?

Answer 10

Bile plug and feathery degeneration (bile salt destruction),

Question 11

What finding is specific to mechanical obstruction leading to cholestasis?

Answer 11

Bile infarct