Tumores del mediastino: Mesotelioma Flashcards

1
Q

Generalidades mesotelioma:

A
  • Raro
  • Sobrevida global de 1 año
  • 10% viven 5 años
  • Hombres 3/1 mujeres
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2
Q

Factores de riesgo:

A
  • Tabaquismo, asbesto, tabaquismo + asbesto, genéticos (BAP1)
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3
Q

Tipos histopatológicos:

A
  • Epitelial
  • Sacromatoide
  • Mixto
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4
Q

Marcadores diagnósticos positivos:

A
  • Calretinina
  • WT1
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5
Q

Marcadores diagnósticos negativos:

A
  • TTF1
  • ACE
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6
Q

Factores pronósticos (CALGB)

A
  • Edad
  • ECOG
  • Hg sérica
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7
Q

Grupo 1 (CALGB):

A
  • ECOG 0, edad menor a 49, Hb += 14.5
  • SG 13 meses
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8
Q

Grupo 6 (CALBG):

A
  • ECOG 1-2, Leucos += 15.6
  • SG: 1.4 meses
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9
Q

Clinica al diagnóstico:

A
  • Disnea
  • Tos
  • Dolor
  • Edema facial y extremidades inferiores
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10
Q

Estudios b{asicos:

A
  • TAC torax/abdomen
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11
Q

Estudios antes del tx multimodal:

A
  • PET FDG
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12
Q

Hasta el estadio ___ se puede operar

A
  • TIII
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13
Q

Mejor tratamiento para mesotelioma:

A

Trimodal (Qt, Tx y RT)

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14
Q

Segun lo estudios realizados, tanto el epiteloide, como el no epiteloide, el mejor tratamiento son los:

A

ICI bimodal –> nuevo estandar

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