Tumor Suppressors Flashcards by Ben Jones | Brainscape

Q

Rb

A

inhibits E2F; blocks G1 -> S-phase

retinoblastoma, osteosarcoma

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Q

p53

A

transcription factor for p21; blocks G1 -> S-phase

Most cancers, Li-Fraumeni syndrome

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Q

BRCA1, BRCA2

A

DNA repair protein

breast, ovarian cancers

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Q

p16

A

melanoma

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Q

BRAF

A

B-raf

melanoma

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Q

APC

A

colorectal cancer (associated with FAP)

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Q

WT1

A

Wilm’s tumor (nephroblastoma)

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Q

NF1

A

RAS GTPase-activating protein

neurofibromatosis I

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Q

NF2

A

Merlin (schwannomin) protein

neurofibromatosis II

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Q

DPC4

A

pancreatic cancer

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Q

DCC

A

colon cancer

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