Anemias

Question 1

Microcytic

Answer 1

Iron deficiency, ACD, thalassemias, lead poisoning, sideroblastic

Question 2

Normocytic/Nonhemolytic

Answer 2

ACD, aplastic anemia, chronic kidney disease

Question 3

Normocytic/Hemolytic/Intrinsic

Answer 3

hereditary spherocytosis, G6PD def., PK def., HbC, sickle cell, PNH

Question 4

Normocytic/Hemolytic/Extrinsic

Answer 4

autoimmune, microangiopathic, macroangiopathic, infections

Question 5

Macrocytic/Megaloblastic

Answer 5

folate def., B-12 def., orotic aciduria

Question 6

Macrocytic/Nonmegaloblastic

Answer 6

liver disease, alcoholism, reticulocytosis

Question 7

Iron deficiency

Answer 7

due to chronic bleeding, malnutrition, increased demand.

decreased iron, ferritin; increased TIBC

Question 8

alpha-thalassemia

Answer 8

mutation in alpha-globin gene.
4 gene deletion = no alpha-globin, all gamma-globin, Hb Barts (g4, hydrops fetalis - no life)
3 gene deletion = HbH disease, excess beta-globin (b4)
1-2 gene deletion = not significant
cis deletion = Asian
trans deletion = African