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Pathology > tumor suppressor genes (name associated tumor and gene product) > Flashcards

tumor suppressor genes (name associated tumor and gene product) Flashcards

loss of function = increased cancer risk both alleles must be lost for expression of disease

1
Q

Rb

A

retinoblastoma, osteosarcoma

inhibits E2F; blocks G1 -> S phase

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2
Q

p53

A

most human cancers, Li-Fraumeni syndrome

transcription factor for p21, blocks G1 -> S phase

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3
Q

BRCA1 and BRCA2

A

breast and ovarian cancer

DNA repair protein

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4
Q

p16

A

melanoma

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5
Q

APC

A

colorectal cancer (associated with FAP)

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6
Q

WT1

A

wilm’s tumor (nephroblastoma)

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7
Q

NF1

A

neurofibromatosis type 1

RAS GTPase activating protein - RAS-GAP

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8
Q

NF2

A

neurofibromatosis type 2

Merlin (schwannomin) protein

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9
Q

DPC4

A

pancreatic cancer

“deleted in pancreatic cancer”

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10
Q

DCC

A

colon cancer

“deleted in colon cancer”

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Pathology (11 decks)

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