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Pathology > tumor markers & IHC stain markers > Flashcards

tumor markers & IHC stain markers Flashcards

tumor markers should not be used as the primary tool for cancer diagnosis they may be used to confirm diagnosis, to monitor for tumor recurrence, and to monitor response to therapy

1
Q

PSA

A 
prostatic epithelium
(prostate-specific antigen)

used to follow prostate carcinoma
can also be elevated in BPH and prostatitis

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2
Q

prostatic acid phosphatase

A

prostate carcinoma

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3
Q

CEA

A

carcinoembryonic antigen

very nonspecific but produced by ~70% of colorectal and pancreatic cancers; also produced by gastric, breast, and medullary thyroid carcinomas

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4
Q

a-fetoprotein

A

normally made by fetus
hepatocellular carcinomas
nonseminomatous germ cell tumor (ie: testis, ovary)

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5
Q

B-hCG

A

hydatidiform moles, choriocarcinomas

gestational trophoblastic disease

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6
Q

CA-125

A

ovarian CA

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7
Q

S-100

A

melanoma, neural tumors, schwannomas

pathoma + langerhans cell histiocytosis

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8
Q

alkaline phosphatase

A

metastases to bone, liver, paget’s disease of bone

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9
Q

bombesin

A

neuroblastoma, lung CA, gastric CA

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10
Q

TRAP

A

tartrate-resistant acid phosphatase (TRAP)

hairy cell leukemia (B-cell neoplasm)

“TRAP the hairy animal”

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11
Q

CA-19-9

A

pancreatic adenocarcinoma

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12
Q

calcitonin

A

medullary thyroid carcinoma

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13
Q

keratin

A

epithelium

IHC stain

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14
Q

vimentin

A

mesenchyme

IHC stain

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15
Q

desmin

A

muscle

IHC stain

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16
Q

GFAP

A

neuroglia

IHC stain

17
Q

neurofilament

A

neurons

IHC stain

18
Q

ER

A

breast epithelium

IHC stain

19
Q

thyroglobulin

A

thyroid follicular cells

IHC stain

20
Q

chromogranin

A 
neuroendocrine cells
(IHC stain)

(ie small cell carcinoma of lung and carcinoid tumors)

21
Q

MPO

A

AML
(myeloid blasts)

Adults

22
Q

TdT

A

ALL
(lymphoblasts)

Children

23
Q

CD34+

A

Hematopoietic stem cell

24
Q

Markers of B-ALL

A

TdT+

CD10, CD19, CD20

25
Q

Markers of T-ALL

A

TdT+

CD2-8

26
Q

Auer rods

A

AML

27
Q

Markers of CLL

A

CD5 and CD20

Naive B cells

28
Q

Lytic bone lesions

WITH OR WITHOUT RASH

A

WITH: ATLL (mature CD4)

WITHOUT: multiple myeloma

29
Q

Markers of Hodgkin Lymphoma

A

Reed-Sternberg cells

CD15 and CD30

30
Q

Markers of langerhans cells

A

CD1a+ and S100+

Pathology (11 decks)

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