chemical carcinogens (name organ and impact on that organ) Flashcards
aflatoxins
LIVER - hepatocellular carcinoma
derived from aspergillus, which can contaminate stored rice and grains
vinyl chloride
LIVER - angiosarcoma
carbon tetrachloride
LIVER - centrilobular necrosis, fatty change
nitrosamines (smoked foods)
STOMACH - gastric cancer
cigarette smoke
LARYNX - squamous cell carcinoma LUNG - squamous cell and small cell carcinoma KIDNEY - renal cell carcinoma BLADDER - transitional cell carcinoma PANCREAS - pancreatic adenocarcinoma
asbestos
LUNG - bronchogenic carcinoma > mesothelioma
arsenic
SKIN - squamous cell carcinoma
LIVER - angiosarcoma
lung cancer
naphthalene (aniline) dyes
BLADDER - transitional cell carcinoma
alkylating agents
BLOOD - leukemia/lymphoma
alcohol
SCC of oropharynx and upper esophagus
hepatocellular carcinoma
nickel, chromium, beryllium, silica
LUNG carcinoma
IONIZING radiation (nuclear reactor accidents and radiotherapy)
AML
CML
papillary carcinoma of thyroid
NONIONIZING radiation (UVB most commonly)
skin - BCC, SCC, and melanoma