oncogenes (name associated tumor and gene product) Flashcards
gain of function = increased cancer risk need damage to only 1 allele
1
Q
abl
A
CML
and some types of ALL
(tyrosine kinase)
2
Q
c-myc
A
burkitt’s lymphoma
transcription factor
3
Q
bcl-2
A
follicular and undifferentiated lymphomas
anti-apoptotic molecule
4
Q
HER-2/neu
c-erbB2
A
breast, ovarian, and gastric carcinomas
tyrosine kinase
5
Q
ras
A
colon carcinoma
(GTPase)
Pathoma: carcinomas, melanoma, lymphoma
6
Q
l-myc
A
lung tumor (small cell) (transcription factor)
7
Q
n-myc
A
neuroblastoma
transcription factor
8
Q
ret
A
multiple endocrine neoplase (MEN) types 2A and 2B
sporadic medullary carcinoma of thyroid
(tyrosine kinase)
9
Q
c-kit
A
gastrointestinal stromal tumor (GIST)
cytokine receptor
10
Q
BRAF
A
melanoma
BRAF is a proto-oncogene - b-raf
11
Q
PDGFB
platelet derived growth factor
A
astrocytoma
12
Q
ERBB2 (HER2/neu)
epidermal growth factor receptor
A
subset of breast carcinomas
13
Q
CCND1
cyclin D1
A
mantle cell lymphoma
14
Q
CDK4
cyclin dependent kinase
A
melanoma
